| 谷海媛,刘杰,马双成,王淼,高慧媛,郑健.黄芪的研究进展及其质量标志物的预测分析[J].中国药事,2023,(10):1180-1192 |
| 黄芪的研究进展及其质量标志物的预测分析 |
| Research Progress of Astragali Radix and Prediction Analysis of Its Quality Markers |
| 投稿时间：2022-11-02 |
| DOI：10.16153/j.1002-7777.2023.10.010 |
| 中文关键词: 黄芪 黄酮 多糖 炮制 网络药理学 质量标志物 质量控制方法 评价体系 |
| 英文关键词: Astragali Radix fl avonoids polysaccharides processing network pharmacology quality marker quality control method evaluation system |
| 基金项目:大同市重点研发计划项目（编号 2022022） |
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| 中文摘要: |
| 目的：对近年来黄芪的研究进行总结分析，并结合质量标志物（Q-Marker）概念对黄芪的 Q-Marker进行预测分析，为建立黄芪的质量控制体系提供参考依据。方法：查阅国内外相关文献，梳理分析，对黄芪的本草考证、化学成分、药理作用和质量控制现状进行归纳综述，并从黄芪质量传递与溯源、成分有效性、不同生长年限和产区、网络药理学等多个方面进行其Q-Marker的预测，对黄芪的潜在作用靶点与通路进行分析。结果与结论：综合以上研究，发现黄芪的化学成分复杂，包含黄酮类、多糖类、皂苷类和氨基酸等；药理活性多样，具有抗肿瘤、保护心血管、抗衰老和免疫调节等药理作用。 但是现行质量标准中质量控制指标单一，存在局限性，因此，应建立安全、科学、有效的质量控制方法及品质评价体系。通过预测分析，建议将黄芪多糖、毛蕊异黄酮、槲皮素、芒柄花素、山柰酚、芒柄花苷、正己醛作为黄芪Q-marker的参考。黄芪的化学成分和药理作用研究较多，但黄芪炮制品的药理研究较少，应扩大其炮制品的研究范围。 |
| 英文摘要: |
| Objective: To summarize and analyze the research progress of Astragali Radix in recent years, and predict and analyze the quality marker of Astragali Radix in combination with the concept of quality marker (Q-Marker), in order to provide a reference for the establishment of a scientifi c quality control system for Astragali Radix. Methods: Through reviewing relevant domestic and foreign literatures, combing and analyzing, summarized the textual research, chemical constituents, pharmacological eff ects and quality control status of Astragali Radix, predicted its quality markers from many aspects such as the quality transfer and traceability of Astragali Radix, the effectiveness of ingredients, different growth years and production areas, and network pharmacology, and analyzed the potential targets and pathways of Astragali Radix. Results and Conclusion: Based on the above studies, it is found that the chemical composition of Astragali Radix is complex,including flavonoids, polysaccharides, saponins and amino acids, with diverse pharmacological activities, and has pharmacological effects such as anti-tumor, cardiovascular protection, anti-aging and immune regulation. However, the quality control indicators in the current quality standards are single and have limitations. Therefore, a safe, scientifi c and eff ective quality control method and quality evaluation system should be established. Through the prediction and analysis, it is suggested that astragalus polysaccharides, stamen isofl avones, quercetin, stilbene, kaempferol, stilbene and n-hexanal should be taken as the reference of astragalus Q-marker. There are many studies on the chemical constituents and pharmacological effects of Astragali Radix, but the pharmacological studies on the processed products of Astragali Radix are few, so the research scope of its processed products should be expanded. |
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