| 陈世伟,王长之,刘超,陈晓博.甲氧氯普胺不良反应中文文献分析[J].中国药事,2020,34(10):1231-1236 |
| 甲氧氯普胺不良反应中文文献分析 |
| Chinese Literature Analysis on Adverse Reactions of Metoclopramide |
| |
| DOI：10.16153/j.1002-7777.2020.10.017 |
| 中文关键词: 甲氧氯普胺 不良反应 文献分析 |
| 英文关键词: metoclopramide adverse drug reaction literature analysis |
| 基金项目:河南省科技攻关项目(编号 192102310421) |
|
| 摘要点击次数: 576 |
| 全文下载次数: 158 |
| 中文摘要: |
| 目的：探讨甲氧氯普胺导致不良反应的特征及规律，为临床安全用药提供参考。方法：以“甲氧氯普胺”或“胃复安”和“安全性”或“不良反应”“副作用”等检索词进行组合，检索中国知网数据库、万方数据库、维普数据库，按照设定的文献纳入和排除标准进行筛选，提取病例信息进行统计分析。结果：共纳入文献48篇，提取病例62例。各年龄段男女患者性别分布差异无统计学意义(P＞ 0.05)。患者年龄主要集中在15~44岁(占41.94%)，其次为14岁以下儿童(占25.81%)，且儿童超剂量用药现象较为普遍。不良反应主要累及中枢及外周神经系统，主要临床表现为锥体外系反应。结论：临床应重点关注儿童患者，避免超剂量用药行为，并加强对锥体外系反应症状的关注，避免误诊。生产企业应加强风险研究，完善说明书中儿童用药年龄及用量等信息，补充对锥体外系反应的具体临床症状的描述，为临床安全用药、正确诊疗提供参考。 |
| 英文摘要: |
| Objective: To provide technical support for clinical safe medication by investigating the characteristics and mechanism of adverse reactions induced by metoclopramide. Methods: “Metoclopramide”, “safety”, “adverse reaction” and “side effect”, etc. were used as key words to search and retrieve articles in the CNKI database, Wanfang database and VIP Chinese full-text database. The literature was screened according to the established criteria for inclusion and exclusion of documents, and the case information was extracted for statistical analysis. Results: A total of 48 articles were included and 62 cases were extracted. There was no significant difference in gender distribution between male and female patients of all ages(P＞0.05). The patients were mainly aged 15-44 years old (41.94%), followed by children under 14 years old (25.81%). The phenomenon of overdose medication was rateher common in children. ADR mainly involved the central and peripheral nervous system, and the main clinical manifestations were extrapyramidal reactions. Conclusion: Clinicians should focus on children patients, avoid overdose medication, and pay attention to symptoms of extrapyramidal reactions so as to avoid misdiagnosis. The manufacturers should strengthen risk research, revise the information about the age and dosage of children's medication in the instruction manual, and supplement the descriptions of specific clinical symptoms of extrapyramidal reactions, so as to provide references for clinical safe medication and correct diagnosis and treatment. |
|
查看全文
查看/发表评论 下载PDF阅读器 |
| 关闭 |
|
|
|