| 张婷,卢岩,陈娟,欧阳昭连.PD-1/PD-L1抑制剂领域技术创新态势及其科学基础研究[J].中国药事,2020,34(10):1171-1179 |
| PD-1/PD-L1抑制剂领域技术创新态势及其科学基础研究 |
| Technological Innovation and Its Scientific Basis of PD-1/PD-L1 Inhibitors |
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| DOI：10.16153/j.1002-7777.2020.10.008 |
| 中文关键词: PD-1/PD-L1抑制剂 肿瘤免疫 专利分析 技术创新 科学基础 |
| 英文关键词: PD-1/PD-L1 inhibitors cancer immunotherapy patent analysis technological innovation scientific basis |
| 基金项目:中国医学科学院中央级公益性科研院所基本科研业务费专项“基于专利地图和技术路线图抗肿瘤药技术预测研究”(编号2017PT63006)；中国医学科学院医学与健康科技创新工程课题(编号 2016-I2M-2-004)；国家重点研发计划(编号 2016YFC0104805) |
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| 中文摘要: |
| 目的：通过对PD-1/PD-L1抑制剂的专利分析来揭示其技术创新态势及科学基础来源。方法：采用专利计量分析结合定性分析的方法对PD-1/PD-L1抑制剂的专利从时间趋势、区域分布、技术开发热点及其网络分析等角度进行分析。结果与结论：PD-1/PD-L1抑制剂领域共有专利申请5502项，专利申请逐年增长；技术开发主要集中在美国和中国；技术开发热点以活性和抗体研究为主，且抗肿瘤活性研究的竞争优势相对较强；科学基础研究主题主要集中在三个方向，即肿瘤免疫联合治疗、PD-1/PD-L1 通路在肿瘤免疫逃逸中的机制研究、PD-1/PD-L1抑制剂在非小细胞肺癌中的临床研究。通过对PD-1/ PD-L1抑制剂领域的专利进行分析，揭示其技术创新态势及其科学基础来源，从情报学角度为肿瘤免疫治疗研发提供信息支撑。 |
| 英文摘要: |
| Objective: To discuss the technological innovation trend and its scientific basis of PD-1/PD-L1 inhibitors through patent analysis. Methods: A combination of qualitative and quantitative patent analysis was used to analyze PD-1/PD-L1 inhibitor patents in terms of time trend, regional distribution, hotspots of technology development and network analysis. Results and Conclusion: The results show that there were 5502 patent applications in the field of PD-1/PD-L1 inhibitors, and patent applications have been increasing year by year. Technology development was mainly concentrated in the United States and China; technology development hotspots focused on activity and antibody research, and the competitive advantage of antitumor activity research was relatively strong. The research topics of scientific basis were mainly concentrated on three directions: combined cancer immunotherapy, the mechanism of PD-1/PD-L1 pathway in tumor immune escape, and the clinical study of PD-1/PD-L1 inhibitors in non-small cell lung cancer. This article discusses the technological innovation trend and its scientific basis of PD-1/PD-L1 inhibitors from the perspective of information science based on patent analysis, and provides information support for cancer immunotherapy research and development. |
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