| 张才煜,耿颖,卢日刚,何兰.核磁共振定量法测定茶苯海明的含量[J].中国药事,2018,32(6):743-746 |
| 核磁共振定量法测定茶苯海明的含量 |
| Quantitative Determination of the Content of Dimenhydrinate by qNMR |
| 投稿时间：2017-12-05 |
| DOI：10.16153/j.1002-7777.2018.06.008 |
| 中文关键词: 核磁定量法 茶苯海明 含量测定 对照品 |
| 英文关键词: quantitative nuclear magnetic resonance dimenhydrinate determination of content reference material |
| 基金项目: |
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| 中文摘要: |
| 目的：建立定量核磁共振波谱法同时测定茶苯海明中苯海拉明和8-氯茶碱的方法。方法：以对苯二酚为内标，氘代甲醇为溶剂，分别采用苯海拉明中的δ2.89的甲基峰与8-氯茶碱中的δ3.47的甲基峰和内标峰的比值计算含量。结果：该方法精密度小于0.6%，线性相关系数（r）均为0.9999，实际测定茶苯海明原料药中的苯海拉明与8-氯茶碱的含量分别为54.04%与45.37%。结论：本文建立的核磁定量法快速、简单、准确，为该品种的含量测定提供了新的方法。 |
| 英文摘要: |
| Objective:To establish a quantitative nuclear magnetic resonance spectroscopic (qNMR) method for simultaneous determination of diphenhydramine and 8-chlorotheophylline in dimenhydrinate. Methods:Hydroquinone was used as internal standard and deuterated methanol was used as solvent. The ratios of methyl peak of δ 2.89 in diphenhydramine and the methyl peak of δ 3.47 in 8-chlorotheophylline with internal standard peak were used to calculate the contents respectively. Results:The precision of the method was less than 0.6% and the linear correlation coefficient (r) was 0.9999. The actual content of diphenhydramine and 8-chlorotheophylline in the raw material of dimenhydrinate was 54.04% and 45.37%, respectively. Conclusion:The qNMR method established in this paper is a rapid, simple and accurate method, which provides a new way to determine the content of the dimenhydrinate. |
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