| 梁婉宁,王匀,黄海玲,彭俊云.HAART治疗艾滋病患者的药物安全性及疗效分析[J].中国药事,2017,(8):965-968 |
| HAART治疗艾滋病患者的药物安全性及疗效分析 |
| Drug Safety and Efficacy of HAART Treatment for HIV/AIDS Patients |
| 投稿时间：2016-08-01 |
| DOI：10.16153/j.1002-7777.2017.08.022 |
| 中文关键词: 高效抗逆转录病毒疗法 艾滋病 病毒载量 抗病毒疗效 替诺福韦 拉米夫定 依非韦伦 |
| 英文关键词: HAART HIV/AIDS viral load antiviral effect TDF 3TC EFV |
| 基金项目:广东省肇庆市科技局基金项目（编号2016040301-01） |
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| 中文摘要: |
| 目的：探究艾滋病（AIDS）患者使用高效抗反转录病毒疗法（highly active antiretroviral therapy，HAART）后的安全性及其疗效。方法：选择2011年5月至2014年5月在我院进行免费HAART治疗的27例HIV-1晚期患者，即用替诺福韦+拉米夫定+依非韦伦的药物治疗，疗程为1~2年，平均18个月。其后进行了6个月到2年的随访，定期监测HIV-RNA病毒载量、CTL（HIV特异性细胞毒性T淋巴细胞）应答、CD4+T淋巴细胞计数、常规生化指标和临床观察指标等。结果：27例患者临床症状均明显改善，70.4%（19/27）的患者HIV-RNA病毒载量< 50拷贝/mL，CD4+T淋巴细胞计数平均为276±129个/μL，CTL在每个蛋白区均有较高应答频率和相关效应。常规生化指标和临床观察指标基本恢复正常。结论：HAART有较好的抗病毒疗效，免疫重建效果也很好，可以大大降低艾滋病的机会感染和死亡率，提高病人的生活质量。 |
| 英文摘要: |
| Objective: To explore the safety of drug use of effective antiretroviral therapy (highly active antiretroviral therapy, HAART) in patients with HIV/AIDS and its curative effect. Methods: From May 2011 to May 2014, 27 patients with advanced HIV-1 were treated with a free HAART therapy for 1~2 years in our hospital, by using TDF, 3TC, EFV drugs treatment for 18 months in average. They were followed up for 6 months to 2 years by regular monitoring of HIV-RNA viral load, CTL (HIV specific cytotoxic T lymphocyte) response, CD4+T lymphocyte count, routine biochemical indicators and clinical observation indicators, etc. Results: During the follow-up, the clinical symptoms of 27 patients were all significantly improved, and 70.4% (19/27) of the patients had an HIV-RNA viral load of less than 50 copies/ml. The average CD4+T lymphocyte count was 276 ±129/μ L. CTL had a high response frequency and correlation effect in each protein region. Routine biochemical index and clinical observation index basically returned to normal. Conclusion: HAART had relatively good antiviral effect, and the immune reconstitution effect was also very good. It could greatly reduce the chance of infection and mortality and improve the quality of life of patients. |
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