| Objective: Using network pharmacology methods to explore the mechanism of Qingfei Jiedu Tang(QFJDT) in treating PF. Methods: The TCMSP database was used to obtain the active ingredients of the QFJDT formulation and the targets were predicted using the Swiss Target Prediction data platform. GeneCards database was used to collect targets related to pulmonary fibrosis and compare them with the drug action targets to screen out common parts as predicted targets for drug ingredient action. Then, Cytoscape 3.6.1 was used to draw the "drug-component-disease-target" network diagram, construct the protein-protein interaction (PPI) network, and screen out the core targets. Finally, GO functional enrichment and KEGG pathway enrichment analyses were carried out for the potential targets, and the component-target-pathway network was established, and molecular docking of core compounds was carried out for the key targets. Results: We obtained 280 active ingredients and 6,673 targets of QFJDT from TCMSP; 5,149 lung fibrosis-related genes from GeneCards database; 224 key targets of QFJDT in treating lung fibrosis by constructing a "drug-ingredient-disease-target" network; and 3,340 biological processes related to QFJDT in treating lung fibrosis, including antioxidant response to reactive oxygen species, etc., were identified by GO enrichment analysis. The GO enrichment analysis revealed that the treatment of pulmonary fibrosis by QFJDT is related to 3340 biological processes, including antioxidant response and response to reactive oxygen species. KEGG enrichment involved 164 signalling pathways, indicating that QFJDT mainly exerts its therapeutic effect on pulmonary fibrosis through the AGEs-RAGE signalling pathway in diabetic complications, etc. Finally, molecular docking of arachidonic acid 5-lipoxygenase target proteins with the 15 major active ingredients in QFJDT revealed that several components, such as cellulose, coumarin C, and kaempferol, showed good affinity, suggesting that they have a direct action relationship with the known targets of PF. Conclusion: QFJDT contains a number of pharmacodynamic components with inhibitory effects on PF, which can exert pharmacodynamic effects through a multi-component and multi-target synergistic mechanism of action. This paper can further provide a reference for the study of the pharmacodynamic material basis and target of action of QFJDT for the treatment of PF. |