| 马天宇,肖智杰,段卓然,常梓睿,牟景龙,孟永海,翟春梅.泻白散质量标志物的发现及其作用机制预测分析[J].中国药事,2024,38(2):189-200 |
| 泻白散质量标志物的发现及其作用机制预测分析 |
| Discovery of Q-markers of Xiebai Powder and Predictive Analysis of Its Mechanism of Action |
| 投稿时间：2023-06-05 |
| DOI：10.16153/j.1002-7777.2024.02.010 |
| 中文关键词: 泻白散 五原则 质量标志物 作用机制 网络药理学 |
| 英文关键词: Xiebai Powder fi ve principles Q-markers action mechanism network pharmacology |
| 基金项目:哈尔滨市科技创新人才研究专项资金项目（编号 2017RAQXJ125）；黑龙江中医药大学研究生创新科研项目（编号 2022yjscx055）； 黑龙江省博士后科研启动金资助项目（编号 LBH-Q15137） |
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| 中文摘要: |
| 目的 ： 旨在明确泻白散质量标志物并预测其作用机制，确保临床疗效。 方法： 通过 Q-markers“五原则”筛选泻白散质量标志物；采用TCMSP、Swiss Target Prediction等数据库获取 Q-markers潜在作用靶点，构建质量标志物的蛋白互作网络。通过KEGG、GO、拓扑富集分析构建“关键靶点-关键通路-关键生物过程”网络，进而预测泻白散质量标志物的潜在作用机制。结果：研究显示，氧化白藜芦醇、绿原酸、阿魏酸、甘草素、甘草酸和芒柄花素6个化合物可作为泻白散的潜在质量标志物，这些物质可能通过调节炎症反应中的一氧化氮生物合成过程、AGEs-RAGE信号通路等途径发挥作用。结论：通过初步探讨泻白散的质量标志物及其作用机制，为泻白散质量控制与临床应用提供科学依据。 |
| 英文摘要: |
| Objective: To identify Q-markers and predict their mechanisms of action to ensure clinical effi cacy. Methods: The quality markers for Xiebai Powder were screened by Q-markers "Five Principles". Databases such as TCMSP and Swiss Target Prediction were used to obtain potential targets of Q-markers, in order to construct a protein interaction network for Q-markers. Through KEGG, GO, and topological enrichment analysis, the"key target-key signal pathway-key biological process" network was constructed to predict the potential mechanism of the Q-markers of Xiebai Powder. Results: This study showed that oxyresveratrol, chlorogenic acid, ferulic acid, liquiritigenin, glycyrrhizic acid and formononetin could be used as potential quality markers of Xiebai Powder. These substances might play a role in regulating the nitric oxide biosynthesis process and AGEs-RAGE signaling pathway in inflammatory response. Conclusion: This article preliminarily explores the quality markers and mechanism of Xiebai Powder, aiming to provide scientifi c basis for the quality control and clinical application of Xiebai Powder. |
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