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| 菊苣酸治疗代谢性疾病药理作用研究进展 |
| Therapeutic Effect of Chicoric Acid on Metabolic Diseases: A Review of Pharmacological Data |
| 投稿时间：2024-04-07 修订日期：2024-06-20 |
| DOI： |
| 中文关键词: 菊苣酸 代谢性疾病 研究进展 |
| 英文关键词: Chicoric acid metabolic diseases research progress |
| 基金项目:山东省自然科学基金项目（ZR2021QH111）；山东省医药卫生科技发展计划项目（202013030996）；威海市中医药科技项目（2022N-15；2023Ⅲ-17）；2022年全国名老中医药专家传承工作室建设项目（国中医药人教函〔2022〕75号）；山东药品食品职业学院项目（Y2022Y05；Y2023Y01） |
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| 中文摘要: |
| 代谢性疾病是一类由物质或能量代谢异常引起的全身多系统代谢异常的疾病,包括糖尿病、肥胖、非酒精性脂肪性肝病、高脂血症、痛风等。代谢性疾病的病因与遗传、饮食、运动、衰老和环境等众多因素相关,其病程发展缓慢不易察觉且发病后难以治愈,已经成为全球主要的公共卫生问题。从天然化合物中寻找治疗代谢性疾病的有效药物具有重要意义。菊苣酸为蒲公英、菊苣等多种天然药用植物中的重要活性成分,现代药理学研究表明,菊苣酸在抗炎、抗氧化、平衡糖脂代谢、降尿酸、肝脏保护等方面具有显著的生物活性。该文通过汇总国内外相关文献,全面综述了菊苣酸在治疗糖尿病、肥胖、非酒精性脂肪性肝病、高脂血症、痛风相关代谢性疾病的研究进展,该文旨在为菊苣酸治疗代谢性疾病药理作用的深入研究提供参考。 |
| 英文摘要: |
| Metabolic diseases are systemic multi-system disorders caused by abnormal metabolism of substances or energy, including diabetes, obesity, non-alcoholic fatty liver disease, hyperlipidemia, and gout. The causes of metabolic diseases are related to multiple factors such as genetic element, diet, exercise, aging and environment. Metabolic diseases, with slow disease progress, are not easy to detect and difficult to cure after onset, which have become major public health issues worldwide. It is of great significance to find effective drugs from natural compounds to treat metabolic diseases. Chicoric acid is an important active ingredient in Taraxacum mongolicum，Cichorium intybus and other natural medicinal plants. Modern pharmacological research suggests that chicoric acid has significant bioactivities such as anti-inflammatory and antioxidant properties, regulating glucose and lipid metabolism, lowering uric acid and liver protection. This paper summarized the research progress on the therapeutic effect of chicoric acid on metabolic diseases such as diabetes, obesity, non-alcoholic fatty liver disease, hyperlipidemia and gout through a comprehensive review of relevant literature in China and abroad. This paper aims to provide reference for further study of the pharmacological effects of chicoric acid in the treatment of metabolic diseases. |
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