文章摘要
杨卜嘉,于传飞,侯书婷,石慧,王兰.IL-33/ST2信号通路及相关药物研究进展[J].中国药事,2024,38(1):96-104
IL-33/ST2信号通路及相关药物研究进展
Research Advances in IL-33/ST2 Signaling Pathway and Related Drugs
投稿时间:2023-05-21  
DOI:10.16153/j.1002-7777.2024.01.013
中文关键词: L-33/ST2信号通路  发病机制  疾病治疗  靶向药物
英文关键词: IL-33/ST2 signaling pathway  pathogenesis  disease treatment  targeted drugs
基金项目:国家重点研发计划(编号 2021YFF060084)
作者单位
杨卜嘉 烟台大学烟台 264000 
于传飞 中国食品药品检定研究院北京 102629 
侯书婷 中国食品药品检定研究院北京 102629 
石慧 烟台大学烟台 264000 
王兰 中国食品药品检定研究院北京 102629 
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中文摘要:
      目的:介绍IL-33/ST2信号通路,总结其与各项疾病的发生发展机制之间的关系以及相关药物的研发进展,为相关疾病的治疗策略提供新的思路。方法:通过汇总分析现有的研究IL-33/ST2信号通路与多种疾病的发病机制关联的文献,对IL-33/ST2信号通路与各项疾病之间的关系以及相关药物的研发进展进行讨论总结。结果与结论:IL-33作为免疫反应和细胞损伤的警报分子,其信号转导通路在过敏性疾病、慢性炎症性疾病、恶性肿瘤和心血管疾病等多种疾病的发病过程中发挥了十分关键的作用,这些研究成果为多种疾病的治疗策略提供了新的思路。多家国内外公司已经开始研发针对IL-33/ST2的靶向药物,绝大多数为单抗药物,且已经进入不同的临床试验阶段,具有重要的应用前景。
英文摘要:
      Objective: To introduce the IL-33/ST2 signaling pathway, its correlation with the occurrence andprogression of various diseases, and the development of the corresponding drugs, and to provide ideas fordeveloping new treatment strategies of related diseases. Methods: Through a summary analysis of the availableliterature on the association between IL-33/ST2 signaling pathway and the pathogenesis of various diseases,the correlation between IL-33/ST2 signaling pathway and diseases and the development of related drugs arediscussed and summarized. Results and Conclusion: IL-33 acts as an alarm molecule for immune response andcell damage, and its signaling pathway plays a critical role in the pathogenesis of various diseases such as allergicdiseases, chronic infl ammation, cancers and cardiovascular diseases. These fi ndings provide new targets and ideasfor developing treatment strategies for a variety of diseases. Companies around the world have begun to developdrugs targeting IL-33/ST2 signaling pathway, most of which are monoclonal drugs and have entered differentclinical trial stages. These drugs have great application prospect.
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