文章摘要
成新平,姚继彬,安方玉,董建华,靳安顺,祝成楼,达明绪.扶正祛邪解毒类中药复方联合新辅助化疗在局部进展期胃癌中调控肿瘤免疫微环境的机制研究进展[J].中国药事,2023,(6):696-704
扶正祛邪解毒类中药复方联合新辅助化疗在局部进展期胃癌中调控肿瘤免疫微环境的机制研究进展
Research Progress on the Mechanism of Regulating Tumor Immune Microenvironment in Locally Advanced Gastric Cancer by Fuzheng Quxie Jiedu Chinese Herbal Compound Combined with Neoadjuvant Chemotherapy
投稿时间：2022-09-07  
DOI：10.16153/j.1002-7777.2023.06.009
中文关键词: 新辅助化疗  中药复方  局部进展期胃癌  肿瘤免疫微环境  免疫抑制
英文关键词: neoadjuvant chemotherapy  Chinese herbal compound  local advanced gastric cancer  tumor immune microenvironment  immunosuppression
基金项目:国家自然科学基金项目(编号 82160588)；甘肃省自然科学基金项目(编号 21R1RA016)
作者单位
成新平 甘肃中医药大学第一临床医学院,兰州 730000 
姚继彬 甘肃省人民医院,兰州 730000 
安方玉 甘肃中医药大学敦煌医学与转化教育部重点实验室,兰州 730000 
董建华 甘肃中医药大学第一临床医学院,兰州 730000 
靳安顺 甘肃中医药大学第一临床医学院,兰州 730000 
祝成楼 甘肃省人民医院,兰州 730000 
达明绪 甘肃省人民医院,兰州 730000 
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中文摘要:
      目的：总结扶正祛邪解毒类中药复方联合新辅助化疗在局部进展期胃癌中调控肿瘤免疫微环境的机制研究进展，期待为进展期胃癌的诊疗与科学研究提供参考。方法：依据中医对胃癌病机及治法认识，总结“健脾益气类、扶正祛邪类及解毒抗癌类”中药复方联合新辅助化疗在进展期胃癌中可能的免疫调控机制。结果：益气扶正解毒类中药复方联合新辅助化疗可通过双向、多靶点、多环节调控免疫细胞，即重塑肿瘤免疫微环境，使癌细胞失去赖以生存的内环境而发生自噬或凋亡，从而达到抗癌的目的。结论：扶正祛邪解毒类中药复方联合新辅助化疗治疗进展期胃癌疗效确切，且安全性良好，具有一定的临床价值。
英文摘要:
      Objective: To summarize the research progress of the mechanism of FuzhengQuxieJiedu Chinese herbal compound combined with neoadjuvant chemotherapy (NAC) in regulating tumor immune microenvironment in locally advanced gastric cancer, it is expected to provide reference for diagnosis, treatment and scientific research of advanced gastric cancer. Methods: According to the understanding of pathogenesis and treatment of gastric cancer in traditional Chinese medicine (TCM), to retrospectively review the possible immunomodulatory mechanism of the combination of “invigorating, supplementingnourishing, detoxifying and anti-cancer” TCM and NAC in advanced gastric cancer. Results: The combination of YiqiFuzhengJiedu traditional Chinese medicine compound and NAC can regulate the immune cells through bidirectional, multitarget and multi-link, that is to say, remodeling the tumor immune microenvironment, cancer cells lose theinternal environment they depend on for survival and undergo autophagy or apoptosis, thus achieving the goal of anticancer. Conclusion: FuzhengQuxieJiedu compound Chinese medicine combined with NAC has defi niteeffi cacy and good safety in the treatment of advanced gastric cancer, which has certain clinical value.
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