| 苏卫,贺双艳.辅酶Q10过饱和自微乳的制备及特性研究[J].中国药事,2022,36(9):1049-1060 |
| 辅酶Q10过饱和自微乳的制备及特性研究 |
| On Preparation and Characteristics of Coenzyme Q10 Supersaturated Selfmicroemulsion |
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| DOI：10.16153/j.1002-7777.2022.09.011 |
| 中文关键词: 辅酶Q10 促过饱和物质 过饱和自微乳化释药系统 粒径 Box-Behnken响应面法 溶解度 稳定性 |
| 英文关键词: coenzyme Q10 supersaturated promoting substances supersaturated self-emulsifying drug delivery system particle size box-behnken response surface methodology solubility stability |
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| 中文摘要: |
| 目的： 制备辅酶Q10过饱和自微乳化释药系统(S-SMEDDS)，并对其体外特性进行研究。 方法：以粒径和自乳化时间为指标，通过Box-Behnken响应面法优化得出最佳SMEDDS处方比例； 再通过考察混合油相中辅酶Q10的饱和溶解度来确定辅酶Q10 SMEDDS处方载药量；最后考察促饱和物质与辅酶Q10 SMEDDS的相容性及乳化后的稳定性，得出加入促饱和物质的种类和用量；并对辅酶Q10 S-SMEDDS的理化特性进行测定。结果：辅酶Q10 S-SMEDDS的最优处方为中链甘油三酯(MCT)-聚氧乙烯醚氢化蓖麻油(Cremophor EL)-辛酸癸酸聚乙二醇甘油酯(Labrasol)配比为30.92∶58.94∶40，辅酶Q10的载药量为8.3%，羟丙甲基纤维素K100(HPMC K100)的加入量为 2%，形成的微乳粒径平均值为28.90 nm，乳化时间平均值为29.49 s，电位平均值为-31.15 mV，溶出度在20 min时达到90.11%。结论：所制备的辅酶Q10 S-SMEDDS可明显提高其溶解度，且乳化后稳定性更好，比普通SMEDDS更具有优势。 |
| 英文摘要: |
| Objective: To prepare Coenzyme Q10 supersaturated self-microemulsion drug delivery system (Coenzyme Q10 S-SMEDDS) and study its in vitro properties. Methods: Taking particle size and selfemulsification time as indicators, the optimal proportion of SMEDDS prescription was obtained through optimizing Box-Behnken response surface methodology; the drug loading of Coenzyme Q10 SMEDDS was determined by investigating the saturated solubility of Coenzyme Q10 in mixed oil phase; Finally, the type and dosage of saturation promoting substances were gotten by investigating the compatibility of saturation promoting substances with Coenzyme Q10 SMEDDS and the stability after emulsification; the physical and chemical properties of Coenzyme Q10 S-SMEDDS were determined. Results: The optimal prescription of Coenzyme Q10 S-SMEDDS is MCT-Cremophor EL-Labrasol (30.92∶58.94∶40). The drug loading of Coenzyme Q10 in SMEDDS is 8.3%, the addition amount of Hydroxypropyl methyl cellulose K100 (HPMC K100) is 2%, the formed microemulsion has an average particle size of 28.90 nm, an average emulsification time of 29.49 s and an average potential of -31.15 mV, and the dissolution rate reaches 90.11% at 20 min. Conclusion: The prepared Coenzyme Q10 S-SMEDDS could significantly improve its solubility, and the stability is better after emulsification. S-SMEDDS has more advantages than ordinary SMEDDS. |
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