| 何玉梅,李薇,朱贺,韩晟.百令胶囊联合西医常规治疗方案治疗慢性肾衰竭的药物经济学研究[J].中国药事,2022,36(8):862-871 |
| 百令胶囊联合西医常规治疗方案治疗慢性肾衰竭的药物经济学研究 |
| Pharmacoeconomic Study of Bailing Capsule Plus Conventional Therapy in Treating Chronic Renal Failure |
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| DOI：10.16153/j.1002-7777.2022.08.003 |
| 中文关键词: 慢性肾衰竭 百令胶囊 Meta分析 成本-效果分析 |
| 英文关键词: chronic renal failure bailing capsule Meta analysis cost- eff ectiveness analysis |
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| 中文摘要: |
| 目的：评估百令胶囊联合西医常规治疗对比西医常规治疗方案治疗慢性肾衰竭的经济性。方法： 基于中国卫生体系角度，通过建立决策树模型开展成本-效果分析，利用Meta分析得出有效性和安全性结果后，综合评价2种治疗方案的短期经济性。有效性指标为总有效率，研究时限为3个月。采用单因素敏感性分析、概率敏感性分析及情境分析评价结果的稳定性。结果：Meta分析结果显示，当治疗时间为 3个月时，百令胶囊组总有效率高于对照组[RR=1.26，95%CI(1.15，1.38)，P＜0.00001]。药物经济学评价结果显示，相比于单用西医常规治疗，百令胶囊联合西医常规治疗的增量成本效果比值为5430元； 敏感性分析结果显示，2个治疗方案的总有效率、百令胶囊的服用剂量及治疗时间对结果的影响较大， 当意愿支付值高于5000元时，百令胶囊联合西医常规治疗更经济的概率高于50%。结论：与单纯西医常规治疗相比，百令胶囊联合西医常规治疗方案对意愿支付值高于5000元的慢性肾衰竭患者来说更经济。 |
| 英文摘要: |
| Objective: To evaluate the economy of Bailing capsule combined with western medicine conventional treatment compared with western medicine conventional treatment in chronic renal failure. Methods: From the perspective of health system in China, cost-effectiveness analysis was conducted by establishing a decision tree model. After the efficacy and safety results were obtained by meta-analysis, the short-term economics of the two treatment regimens were comprehensively evaluated. The effi cacy index was the total eff ective rate and the time horizon was 3 months. One-way sensitivity analysis, probabilistic sensitivity analysis and scenario analysis were used to evaluate the robustness of the results. Results: Meta-analysis shows that when the treatment time was 3 months, the total eff ective rate of Bailing capsule group was higher than that of control group [RR=1.26, 95%CI(1.15, 1.38), P＜0.00001]. Pharmacoeconomic evaluation results shows that compared with the conventional western medicine treatment alone, the ICER value of Bailing Capsule combined with western medicine conventional treatment was 5430 yuan, and sensitivity analysis results show that the total eff ective rate of the two treatments, the dosage of Bailing capsule and the treatment time had great infl uence on the results.When the willingness-to-pay value is higher than 5000 yuan, the probability of Bailing capsule combined with western medicine conventional treatment is more economical than 50%. Conclusion: Compared with western medicine conventional treatment, Bailing capsule combined with western medicine conventional treatment is more economical for patients with chronic renal failure who are willing to pay more than 5000 yuan. |
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