| 孟珠,王涵,何牧野,曾行,王春仁,韩倩倩.间皮细胞及其在腹膜粘连中的作用研究进展[J].中国药事,2021,35(12):1398-1405 |
| 间皮细胞及其在腹膜粘连中的作用研究进展 |
| A Review of Mesothelial Cells and Their Roles in Peritoneal Adhesion |
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| DOI：10.16153/j.1002-7777.2021.12.011 |
| 中文关键词: 腹膜粘连 间皮细胞 巨噬细胞 间皮-间充质转化 机制 |
| 英文关键词: peritoneal adhesion mesothelial cells macrophage MMT mechanism |
| 基金项目:国家重点研发计划课题“组织诱导型生物材料及产品安全有效性评价关键技术研究”(编号 2016YFC1103202) |
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| 中文摘要: |
| 目的： 对间皮细胞的特性、功能和腹膜粘连的形成过程分析归纳，全面探讨间皮细胞在腹膜粘连中发挥的作用。方法：计算机检索Pubmed、中国知网、万方等数据库自2018年1月到2021年10月份收录的与间皮细胞和腹膜粘连有关的文献。对以下检索词任意排列组合，检索词为“间皮细胞，腹膜粘连， 术后粘连，间皮间充质转化，巨噬细胞，防粘连，机制”，共选取53篇文献进行总结归纳。结果：间皮细胞是分布在腹膜表面的细胞，同时具有间充质细胞和上皮细胞的特点，间皮愈合过程不同于上皮愈合，它遵循一种“双峰机制”。当腹膜损伤，间皮层受损，间皮细胞通过不同的受体识别各种炎性反应并释放多种细胞因子、趋化因子、细胞粘附分子、生长因子等炎症介质，经过自分泌、旁分泌等途径诱导自身以及中性粒细胞、巨噬细胞等其他类型细胞增殖、分化和迁移。此外间皮细胞组织型纤溶酶原激活物的分泌减少，纤溶酶原激活物抑制剂-1的释放增加，同时发生间皮-间充质转化，转变为成纤维细胞，产生大量的纤维蛋白、胶原蛋白，胶原形成而机化最终发生腹膜粘连。结论：间皮细胞在腹膜粘连中具有关键性作用，可以寻找一些能促进间皮细胞生长、抑制其间皮-间充质转化、促进其组织型纤溶酶原激活物分泌或抑制纤溶酶原激活物抑制剂-1释放的材料或药物，提升其在粘连预后中的功效，以降低术后粘连并发症的发生率。 |
| 英文摘要: |
| Objective: To analyze and summarize the characteristics and functions of mesothelial cells and the formation process of peritoneal adhesion and to discuss the role of mesenchymal cells in peritoneal adhesion comprehensively. Methods: The literature related to mesothelial cells and peritoneal adhesion from January, 2018 to October, 2021 were searched in Pubmed, CNKI and WanFang databases. Such key terms as“mesothelial cells, peritoneal adhesion, postoperative adhesion, MMT, macrophages, anti-adhesion, and mechanism" were ranked and grouped randomly and searched, and 53 pieces of literature were selected and summarized. Results: Mesothelial cells are cells distributing on the surface of peritoneum and have the characteristics of both mesenchymal cells and epithelial cells. The healing process of mesothelial cells is different from that of epithelial cells and follows a "bimodal mechanism". When the peritoneum and mesothelium are damaged, mesothelial cells recognize variousinflammatory responses through different receptors, release a variety of cytokines, chemokines, cell adhesion molecules, growth factors and other inflammatory mediators and induce the proliferation, differentiation and migration of themselves and other types of cells such as neutrophils and macrophages through autocrine and paracrine pathways. In addition, mesothelial cells could reduce the secretion of tPA and increase the release of PAI-1. At the same time, the mesothelial cells are transformed into fibroblasts by MMT, which produces a large amount of fibrin and collagen. What's more, collagen forms and mechanization eventually lead to peritoneal adhesion. Conclusions: Mesothelial cells play a key role in peritoneal adhesion. Materials or drugs that can promote the growth of mesothelial cells, inhibit their MMT, promote the secretion of tPA or inhibit the release of PAI-1 can be found to improve their efficacy in the prognosis of adhesion so as to reduce the incidence of postoperative adhesion complications. |
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