文章摘要
史宝燕,李彦,李玥.中西药联合治疗帕金森病的研究进展[J].中国药事,2021,35(11):1269-1275
中西药联合治疗帕金森病的研究进展
Research Progress on Integrated Traditional Chinese and Western Therapy for Parkinson’s Disease
  
DOI:10.16153/j.1002-7777.2021.11.009
中文关键词: 帕金森病  西药治疗  中药治疗  中西医结合疗法
英文关键词: Parkinson’s disease  treatment of Western medicines  TCM treatment  integrated traditional Chinese and Western therapy
基金项目:
作者单位
史宝燕 山东中医药大学研究生院,济南 250300 
李彦 山东中医药大学研究生院,济南 250300 
李玥 山东中医药大学附属医院,济南 250014 
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中文摘要:
      帕金森病是一种慢性、不可逆的中枢神经系统退行性疾病,伴有黑质纹状体多巴胺能系统的缓慢退行性变性。表现为脑内黑质多巴胺能神经元缺失、变性或坏死,纹状体多巴胺含量显著降低,以及 α-突触核蛋白错误折叠形成路易小体。帕金森病是一种受遗传和环境因素双重影响复杂的多因素多基因疾病,很大比例的帕金森患者的病因是两者的结合。临床诊断标准是将帕金森病定义为运动迟缓合并静止性震颤、僵直或两者兼有。除上述运动症状外,还表现为便秘、抑郁、嗅觉障碍、睡眠障碍和直立性低血压等非运动症状。目前,没有任何疗法能够阻止帕金森病的进展,多巴胺能药物是治疗帕金森病的首选,但长期使用多巴胺能药物会导致疗效降低和严重的不良反应。中西药联合治疗在减轻帕金森病症状方面比单药治疗更有效,大多能达到增效减毒的效果。帕金森病具有一定的致残性和不可根治性, 影响患者的学习能力和日常工作,对于患者和社会经济都是巨大的负担。因此,探索新的治疗帕金森病的方法、提升患者的生活质量、延缓疾病症状的发展是当前研究的重点问题。
英文摘要:
      Parkinson’s disease is a chronic, irreversible central nervous system degenerative disease with a slow degeneration of the substantia nigra striatum’s dopaminergic system. The main symptoms are loss or, degeneration or necrosis of dopaminergic neurons in substantia nigra, significant decrease of dopamine content in striatum, and formation of Lewy bodies by α-synuclein misfolding. Parkinson’s disease is a complex multifactorial and multigenetic disease that is influenced by both genetic and environmental factors, and a large proportion of Parkinson’s patients are caused by the combination of both. It is defined by clinical diagnosis as bradykinesia with tremor, rigor, or both. In addition to the above dynamic symptoms, it also acts as constipation, depression, dysosmia, sleep disorders and orthostatic hypotension symptoms. At present, no treatment can stop the progression of Parkinson’s disease. Dopaminergic drugs are the first choice for its treatment, but long-term use of dopaminergic drugs will lead to reduced efficacy and serious adverse reactions. The combination of Chinese medicine and Western medicine is more effective than a single medicine in reducing symptoms of Parkinson’sdisease and will achieve the effect of increasing efficacy and decreasing toxicity. Parkinson’s disease is incurable and has a certain degree of disability, which can affect the patients' abilities of learning and daily work, and it is a huge burden to patients and social economy. Therefore, exploring new treatments for Parkinson’s disease, improving patients' life quality, and delaying the development of symptoms of the disease are the focus of the current research.
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