| 荣宝山,黄凯丽,袁琳嫣,王建华,李骁,麻春杰.乌头类药材化学成分和药理作用研究进展[J].中国药事,2021,35(8):932-947 |
| 乌头类药材化学成分和药理作用研究进展 |
| Research Progress on Chemical Composition and Pharmacological Action of Aconitum |
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| DOI：10.16153/j.1002-7777.2021.08.012 |
| 中文关键词: 乌头类药材 化学成分 药理作用 毒性 炮制 |
| 英文关键词: aconitum medicinal materials chemical composition pharmacological action toxicity processing drugs |
| 基金项目:内蒙古自然科学基金(编号 2020LH08033)；内蒙古医科大学青年领创团队项目(编号 QNLC-2020054)；内蒙古医科大学教改课题 (编号 NYJXGG2019042) |
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| 中文摘要: |
| 目的：对乌头类药材成分结构、药理作用和炮制减毒等方面进行探讨分析，为乌头类药材临床用药的安全有效提供参考。方法：通过查阅国内外大量文献，梳理分析，对乌头类药材化学成分、药理作用以及炮制减毒进行综述。结果：乌头类药材的化学成分主要是生物碱，此外还有多糖、皂苷、黄酮等成分。乌头类药材在具有镇痛抗炎、抗肿瘤、免疫调节等药理活性同时又具有心血管、神经等毒性。乌头类药材经过炮制加工在一定程度上可以降低毒性发挥临床药用功效。结论：乌头类药材的化学成分和药理作用的研究已取得一定进展，但对于生物碱构效关系以及更高效的减毒增效炮制方法还需更深入的研究。 |
| 英文摘要: |
| Objective: To discuss and analyze the component structure, pharmacological effects and detoxification of aconitum medicinal materials in order to provide references for the safety and effectiveness of the clinical use of aconitum medicinal materials. Methods: Through reviewing a large number of domestic and foreign literatures in recent years, combing and analyzing, the chemical composition, pharmacological effects and processing and detoxification of aconitum medicinal materials were reviewed. Results: The chemical components of aconitum medicinal materials are mainly alkaloids, in addition to polysaccharides, saponins, and flavonoids. Aconitum medicinal materials have pharmacological activities such as analgesia, anti-inflammation, anti-tumor, and immune regulation, as well as cardiovascular and neurotoxicity. Aconitum medicinal materials can be processed to a certain extent to reduce toxicity and exert clinical medicinal effects. Conclusion: The research on the chemical composition and pharmacological effects of aconitum medicinal materials has made some progress, whereas more in-depth research is needed for the structure-activity relationship of alkaloids and more efficient processing methods for reducing toxicity and increasing efficiency. |
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