| 王莹,刘芫汐,林林,昝珂,金红宇,马双成.采用相对效能因子法对枸杞中拟除虫菊酯类农药的慢性累积暴露评估[J].中国药事,2021,35(6):658-660 |
| 采用相对效能因子法对枸杞中拟除虫菊酯类农药的慢性累积暴露评估 |
| Assessment to Chronic Cumulative Exposure of Pyrethroid Pesticides in Lycium barbarum L. with a Relative Efficacy Factor Method |
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| DOI：10.16153/j.1002-7777.2021.06.007 |
| 中文关键词: 危害指数法 相对效能因子法 枸杞 拟除虫菊酯 累积性评估 |
| 英文关键词: Hazard Index Relative Potency Factor Lycium barbarum L pyrethroid cumulative assessment |
| 基金项目:重大新药创制(编号 2018ZX09303-024) |
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| 中文摘要: |
| 目的：对枸杞中拟除虫菊酯类农药残留带来的累积暴露量进行评估，并探讨相对效能因子法 (RPF)在中药中农药残留累积风险评估中的应用。方法：采用GC-MS/MS法对40批枸杞药材中15种拟除虫菊酯类农药进行检测分析。以溴氰菊酯作为指示农药，采用RPF法，计算拟除虫菊酯类农药的累积暴露量，并与每日允许摄入量(ADI)进行比较，分析风险。同时采用危害指数法(HI)评价累积风险，并对两种方法进行比较。结果：40批枸杞样品中共有4种拟除虫菊酯类农药检出，样品检出率为 84.5%，其中有67.6%的样品中检出2种及以上拟除虫菊酯类农药。通过RPF法和HI法计算得累积风险值分别为0.000205和0.000218，均远低于1，表明累积摄入风险较低。同时发现通过2种方法得出的风险评价一致，但不同方法中各农药的风险贡献值有较大差异，这与2种方法所选择的毒性判断终点不同有关。 结论：通过摄入枸杞中拟除虫菊酯类农药对人体产生的健康风险尚处于可接受水平，并且首次探索了 RPF法在中药农药残留累积评估中的应用，为逐步完善中药中农药残留风险评估系统提供了借鉴。 |
| 英文摘要: |
| Objective: The cumulative exposure to pyrethroid pesticides in Lycium barbarum L. (L. barbarum) was evaluated, and the application of Relative Potency Factor (RPF) method in cumulative risk assessment of pesticide residues in traditional Chinese medicines (TCM) was discussed. Methods: 15 kinds of pyrethroid pesticides from 40 batches of L. barbarum were detected and analyzed by GC-MS/MS. By taking deltamethrin as an indicator pesticide, RPF method was used to calculate the cumulative exposure of pyrethroid pesticides and compare it with the daily allowable intake (ADI) to analyze the risk. The Hazard Index (HI) method was also used to evaluate the cumulative risk, and the two methods were compared. Results: 4 kinds of pyrethroid pesticides were detected out of 40 batches of Lycium barbarum samples, and the detection rate of samples was84.5%, among which 67.6% of the samples contained two or more pyrethroid pesticides. The cumulative risk values calculated by RPF and HI methods were 0.000205 and 0.000218 respectively, which were far lower than 1, indicating that the cumulative intake risk was low. It was found that the risk assessment results obtained by the two methods were consistent, but the risk contribution values of pesticides in different methods were quite different due to the different toxicity judgment endpoints selected by the two methods. Conclusion: The health risk of taking pyrethroid pesticides in L. barbarum is kept at an acceptable level, which provides useful references for the safety supervision of pesticide residues in L. barbarum. The first exploration to the application of RPF method in the cumulative assessment of pesticide residues in TCM will lead to the improvement of the risk assessment system of pesticide residues in TCM. |
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