| 郭媛媛,王苇,朱云腾,王添全,李佳怡,刘蔚,薛春苗,曹俊岭.中药治疗跖疣疗效与安全性的Meta分析[J].中国药事,2020,34(11):1329-1342 |
| 中药治疗跖疣疗效与安全性的Meta分析 |
| Meta-analysis to Efficacy and Safety of Traditional Chinese Medicines for Plantar Warts |
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| DOI：10.16153/j.1002-7777.2020.11.013 |
| 中文关键词: 中药 跖疣 Meta分析 疗效 安全性 |
| 英文关键词: traditional Chinese medicines plantar warts Meta-analysis efficacy safety |
| 基金项目:国家重点研发计划“中医药现代化研究”重点专项(编号 2019YFC1710604)；北京中医药改革专项(编号 201806) |
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| 中文摘要: |
| 目的：通过对临床文献的研究，系统评价中药治疗跖疣的疗效和安全性。方法：采用主题词与自由词相结合的方式，检索The Cochrane Library、Clinical Trials.gov、Pubmed、Web of Science、Springer、 CNKI、CBM、Wan Fang Data、VIP、ChiCTR数据库，收集中药治疗跖疣的随机对照试验，检索日期截至2020年4月15日。采用Cochrane Handbook 5.1(干预措施系统评价手册5.1版)评价纳入研究的方法学质量。采用RevMan5.3软件对结局指标(总有效率、复发率、不良事件发生率)进行meta分析。结果：共纳入51个随机对照试验作为研究对象，所涉及的患者总数为4844例。Meta分析显示：中药(单用或配合其他疗法)与其他疗法(化学药、免疫调节剂、物理疗法等)的疗效比较，临床总有效率高[OR=5.12， 95%CI(3.95,6.63)，Z=12.35，P＜0.00001]，复发率低[OR=0.20，95%CI(0.15,0.28)，Z=9.73，P＜ 0.00001]，不良事件发生率低[OR=0.44，95%CI(0.33,0.60)，Z=5.36，P＜0.00001]。结论：中药治疗跖疣疗效较好，复发率较低，安全性较高。 |
| 英文摘要: |
| Objective: To evaluate efficacy and safety of traditional Chinese medicines in the treatment of plantar warts through studying the clinical literature. Methods: The databases of The Cochrane Library, Clinical Trials. gov, Pubmed, Web of Science, Springer, CNKI, CBM, Wan Fang Data, VIP, and ChiCTR were searched by a combination of MeSH terms and free words up to 15th April, 2020. The randomized controlled trials (RCTs) were identified and extracted by two reviewers independently. The methodological quality of the included studies was assessed by using Cochrane Handbook 5.1. Meta-analysis was used to measure the outcome indexes such as the total effective rates, recurrence rates, and adverse event rates by using RevMan 5.3 software. Results: A total of 51 RCTs involving 4844 patients were included in the research. Meta-analysis showed that traditional Chinese medicines (used alone or combined with other therapies) increased the total effective rates significantly [OR=5.12, 95%CI (3.95, 6.63), Z=12.35, P＜0.00001], decreased the recurrence rates [OR=0.20, 95%CI (0.15, 0.28), Z=9.73, P＜0.00001] and reduced the incidence rate of adverse events [OR=0.44, 95%CI (0.33,0.60), Z=5.36, P＜0.00001], compared with other therapies (chemical medicine, immunomodulator, physiotherapy). Conclusion: The effect of traditional Chinese medicines is beter than that of other therapies with less recurrence rate and adverse event rate. |
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