文章摘要
任霞,王珏,孙会敏,涂家生.表面活性剂临界胶束浓度测定方法的建立和比较[J].中国药事,2020,34(8):916-924
表面活性剂临界胶束浓度测定方法的建立和比较
Establishment and Comparison of A Determination Method of Critical Micelle Concentration for Surfactants
  
DOI：10.16153/j.1002-7777.2020.08.010
中文关键词: 表面活性剂  临界胶束浓度  芘荧光光谱法  表面张力法  电导率法
英文关键词: surfactant  critical micellar concentration  pyrene fluorescence spectrometry  surface tension method  conductivity method
基金项目:国家科技重大新药创制专项(编号 2017zx09101001)
作者单位
任霞 中国药科大学,药用辅料及仿创药物研发评价中心,南京 210009 ；国家药品监督管理局药用辅料质量研究与评价重点实验室,中国食品药品检定研究院,北京 100050 
王珏 国家药品监督管理局药用辅料质量研究与评价重点实验室,中国食品药品检定研究院,北京 100050 
孙会敏 国家药品监督管理局药用辅料质量研究与评价重点实验室,中国食品药品检定研究院,北京 100050 
涂家生 中国药科大学,药用辅料及仿创药物研发评价中心,南京 210009 
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中文摘要:
      目的：临界胶束浓度（Critical Micelle Concentration，CMC）是表面活性剂重要的功能性指标， 本文旨在建立一种适用于离子型和非离子型表面活性剂临界胶束浓度的快速准确的测定方法。方法：采用芘荧光光谱法测定不同类型表面活性剂CMC值，并将结果与传统表面张力法和电导率法结果相比较。 结果：芘荧光法测定不同种类表面活性剂CMC值重复性良好，其测定结果与经典的表面张力法和电导率法测定结果相比无显著性差异。结论：建立了重复性和准确度良好的芘荧光光谱法，该法操作简单、准确度高，可以替代表面张力法及电导率法测定表面活性剂的CMC值。
英文摘要:
      Objective: Critical Micelle Concentration (CMC) is an important functional indicator of surfactants. This paper aims to establish a rapid and accurate method for the determination of critical micelle concentrations of ionic and nonionic surfactants. Methods: Pyrene fluorescence spectrometry was used to determine the CMC values of different types of surfactants, and the results were compared with the traditional surface tension method and conductivity method. Results: The CMC for different kinds of surfactants were determined by pyrene fluorescence method with good repeatability, and the determination results showed no significant difference when compared with the traditional surface tension method and conductivity method. Conclusion: Pyrene fluorescence spectrometry with good repeatability and accuracy has been established. This method is simple and accurate, and can replace the surface tension method and the conductivity method to determine the CMC value of surfactant.
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