文章摘要
罗天宽,岑佳.布地奈德联合美罗培南对新生儿肺炎的临床效果及新生儿肺功能的影响[J].中国药事,2020,34(6):726-730
布地奈德联合美罗培南对新生儿肺炎的临床效果及新生儿肺功能的影响
Clinical Effects of Budesonide Combined with Imipenem on Neonatal Pneumonia and the Influence on Neonatal Pulmonary Function
投稿时间:2019-07-25  
DOI:10.16153/j.1002-7777.2020.06.017
中文关键词: 布地奈德  美罗培南  新生儿肺炎  联合治疗  肺功能
英文关键词: budesonide  imipenem  neonatal pneumonia  combination therapy  pulmonary function
基金项目:
作者单位
罗天宽 乐山市妇幼保健院, 乐山 614000 
岑佳 乐山市妇幼保健院, 乐山 614000 
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中文摘要:
      目的: 分析布地奈德联合美罗培南治疗新生儿肺炎的临床效果及对新生儿肺功能的影响。方法: 回顾性分析2017年5月至2019年5月乐山市妇幼保健院收治的104例新生儿肺炎患儿临床资料,采用随机数字表法将所有患儿分为观察组与对照组,其中对照组单纯选用美罗培南进行治疗,观察组在对照组用药基础上加用布地奈德进行联合治疗。对比两组不同用药方案下临床疗效、各项临床指标及肺功能的差异。结果: 观察组49例患儿均得到有效治疗,治疗总有效率为94.23%,对照组38例患儿得到有效治疗,治疗总有效率为73.08%,观察组临床治疗总有效率明显高于对照组(P<0.05);两组患儿在不同用药方案下均顺利完成治疗,观察组患儿治疗后的临床症状恢复时间及住院时间均明显短于对照组(P<0.05);观察组FVC、FEV1、FEV等肺功能指标水平均明显高于对照组(P<0.05)。结论: 针对新生儿肺炎患儿进行临床治疗时,相较于美罗培南的单独静脉滴注,布地奈德联合美罗培南用药更能提升临床疗效,缩短患儿用药后临床症状复常时间,并减少患儿住院时间,在提高临床治疗安全性的同时较大程度改善了患儿肺功能水平,值得临床推广应用。
英文摘要:
      Objective: To analyze the clinical effects of budesonide combined with imipenem on neonatal pneumonia and the influence on neonatal pulmonary function. Methods: 104 children with neonatal pneumonia treated in our hospital from May, 2017 to May, 2017 were enrolled in the study. All children were divided into the observation group and the control group by random number table. The treatment was performed with imipenem alone in the control group, and the observation group was treated with budesonide combined with imipenem on the basis of the control group. The clinical efficacy, clinical indicators and lung function of the two groups were compared. Results: 49 patients in the observation group underwent effective treatment. The total effective rate was 94.23%. In the control group, 38 patients were treated well with imipenem alone. The total effective rate was 73.08%. The total effective rate of clinical treatment in the observation group was significantly higher than that in the control group (P<0.05). The two groups of children underwent successful treatment with different medication regimens. The recovery time and hospitalization time of the patients in the observation group were significantly shorter than those in the control group (P<0.05). The levels of lung function indexes such as FVC, FEV1 and FEV in the observation group were significantly higher than those in the control group (P<0.05). Conclusion: In the clinical treatment of neonatal pneumonia, compared with the separate intravenous infusion of imipenem, the treatment of budesonide combined with imipenem can improve the clinical efficacy, shorten the recovery time of clinical symptoms after drug treatment, reduce the length of hospitalization, and improve the safety of clinical treatment. Meanwhile, the lung function of children has been greatly improved, so the treatment is worthy of clinical application.
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