| 王彦琦,涂家生,孙春萌.可溶性聚合物微针用于药物经皮递送的研究进展[J].中国药事,2020,34(6):671-679 |
| 可溶性聚合物微针用于药物经皮递送的研究进展 |
| A Review on Dissolving Polymer Microneedles for Transdermal Drug Delivery |
| 投稿时间：2019-09-12 |
| DOI：10.16153/j.1002-7777.2020.06.009 |
| 中文关键词: 可溶性微针 聚合物 经皮 药物递送 |
| 英文关键词: dissolving microneedles polymers transdermal drug delivery |
| 基金项目:国家自然科学基金面上项目（编号81972894、81673364），“重大新药创制”科技重大专项（编号2017ZX09101001006），国家药典委员会（编号ZG2018-5-01） |
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| 中文摘要: |
| 目的： 了解国内外对于可溶性聚合物微针这一新型药物递送系统的研究进展，并对其优势及存在的问题进行分析，对发展前景进行展望。方法： 通过文献调研，总结可溶性聚合物微针的材料及功能，分析可溶性微针所解决的临床用药问题，以及各微针基质材料所具有的优势与面临的挑战。结果： 本文以临床不同的用药需求为视角进行分类，介绍了聚合物材料在可溶性微针递药系统中的应用，并对其优势及面临的挑战进行总结，对发展前景进行展望。结论： 目前对于可溶性聚合物微针的研究已取得了令人瞩目的进展。然而，为实现临床转化，可溶性聚合物微针递药系统的载药能力、安全性等方面仍然需要进一步的研究。 |
| 英文摘要: |
| Objective: To understand the research progress of dissolving polymer microneedles as a new drug delivery system at home and abroad, to analyze its advantages and challenges, and to forecast its development prospect. Methods: Through literature research the materials and functions of dissolving polymer microneedles were summarized, and the clinical medical problems solved by soluble microneedles were analyzed, as well as the advantages and challenges of various microneedle matrix material. Results: This paper classified the application of polymer materials in dissolving microneedles from the perspective of different clinical needs in therapy. The advantages and challenges were summarized, and the development prospect was further concluded. Conclusion: At present, the research on soluble polymer microneedles has made a remarkable progress. However, in order to achieve clinical transformation, further research is needed on the drug loading capacity and safety of the dissolving polymer microneedles systems. |
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