| 刘毅,刘朝霞,吴锐,黄海伟,严菁,林兰.热分析技术研究物质纯度的探讨[J].中国药事,2020,34(3):330-334 |
| 热分析技术研究物质纯度的探讨 |
| Purity Investigation by Thermal Analysis |
| 投稿时间：2019-09-03 |
| DOI：10.16153/j.1002-7777.2020.03.013 |
| 中文关键词: 热分析 纯度 化学标准物质 |
| 英文关键词: thermal analysis purity chemical reference substances |
| 基金项目:中国食品药品检定研究院学科带头人培养基金（编号2015X3） |
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| 摘要点击次数: 813 |
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| 中文摘要: |
| 目的： 探讨热分析技术在纯度研究方面的应用，将其用于化学标准物质的纯度研究。方法： 通过热重分析仪（TGA/SDTA）和差示扫描量热分析仪（DSC）的研究实例，探讨热分析技术的纯度研究方法，TGA/SDTA升温速率为20℃·min-1，气氛N2流速为20 mL·min-1；DSC升温速率为0.5、10℃·min-1，气氛N2流速为50 mL·min-1。结果： 三步骤的过程解析较系统地反映了热分析技术在纯度研究方面的应用。结论： 该方法简明易操作，有助于热分析技术纯度研究方法的应用推广。 |
| 英文摘要: |
| Objective: To study the application of thermal analysis in the purity research and in the purity of chemical reference substances. Methods: Purity examples by thermo gravimetric analysis/simultaneous differential thermal analysis (TGA/SDTA) and differential scanning calorimetry (DSC) for chemical reference substances were analyzed and discussed. Via the analysis with TGA/SDTA, the heating rate was 20℃·min-1, and the gas flow rate of N2 was 20 mL·min-1. Via the analysis with DSC, the heating rates were 0.5℃·min-1 and 10℃·min-1, respectively, and the gas flow rate of N2 was 50 mL·min-1. Results: The three-step process analysis systematically reflected the application of thermal analysis technology in the purity research. Conclusion: The purity research by thermal analysis provided a simple and convenient method for chemical reference substances and other suitable drug substances. It was helpful to the application and popularization of the thermal analysis technology in the purity research. |
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