| 任磊,任亚男,王伟,包晗,王玉琨.某儿童医院167例药品不良反应分析[J].中国药事,2019,33(11):1315-1319 |
| 某儿童医院167例药品不良反应分析 |
| Analysis of 167 Cases of Adverse Drug Reactions in a Children's Hospital |
| 投稿时间：2019-08-22 |
| DOI：10.16153/j.1002-7777.2019.11.015 |
| 中文关键词: 儿童医院 药品不良反应 分析 合理用药 |
| 英文关键词: children's hospital adverse drug reaction analysis rational drug use |
| 基金项目:陕西省自然科学基础研究项目（编号2017JZ023） |
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| 中文摘要: |
| 目的：分析某儿童医院167例药品不良反应的发生情况和特点，为药品不良反应监测与合理用药提供借鉴。方法：采用回顾性分析方法，从呈报人职业、患儿性别与年龄、引发ADR主要药品名称、药品种类、给药途径、联合用药、ADR累及器官/系统及主要临床症状等基本情况进行统计分析。结果：医生是ADR的主要呈报人（96.41%）。男童96例（57.48%）、女童71例（42.52%）。0~3岁患儿98例（58.68%）。引发ADR的前十位药品中居第一和第二位的分别是β-内酰胺类抗生素和营养类药物。引发ADR的主要给药途径是静脉滴注（47.31%）。单一用药53例（31.74%），二药联用110例（65.87%）。ADR累及的器官/系统主要有皮肤及附件损害105例次（60.69%）、全身性损害27例次（15.61%）、消化系统损害11例次（6.36%）。临床症状主要表现为皮疹（49.13%）、过敏（7.51%）、发热（6.94%）等。结论：应强化儿童ADR监测，加强静脉给药、联合用药、抗菌药物使用监管，规范儿童临床药物的合理应用，减少ADR的发生，保障儿童用药安全。 |
| 英文摘要: |
| Objective:To analyze the occurrence and characteristics of 167 adverse drug reactions (ADR) in a children's hospital, so as to provide references for monitoring ADR and rational drug use. Methods:A retrospective analysis method was used to analyze the basic information of ADR, such as occupation of the reporters, gender and age of the children, name of the main drugs causing ADR, types of drugs, route of administration, combination of drugs, main organs/systems involved and main clinical symptoms of ADR. Results:Doctors were the main reporters (96.41%). 96 were boys (57.48%) and 71 were girls (42.52%). 98 cases (58.68%) were children whose ages were between 0 and 3 years old. The first and second of the top 10 drugs that caused ADR were β-lactam antibiotics and nutritional drugs. The main route of administration for ADR was intravenous drip (47.31%). 53 cases (31.74%) of ADR were caused by single drug. 110 cases (65.87%) of ADR were caused by combination of two drugs. The organs/systems involved were as follows:105 cases (60.69%) of skin and appendage injuries, 27 cases (15.61%) of systemic injuries and 11 cases (6.36%) of digestive system injuries. The main clinical symptoms were rash (49.13%), allergy (7.51%), fever (6.94%) and so on. Conclusion:We should strengthen the monitoring of ADR in children, the supervision of intravenous drugs, the combination of drugs and antibiotics, standardize the rational drug use in children in order to reduce the occurrence of ADR and ensure the safety of medication in children. |
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