Abstract Objective: To analyze the occurrence and characteristics of 167 adverse drug reactions (ADR) in a children"s hospital, so as to provide reference for strengthening the monitoring of ADR and rational drug use. Methods: A retrospective analysis method was used to analyze the basic situation of ADR, including the occupation of the presenter, the sex and age of the children, the name of the main drugs causing ADR, the types of drugs, the route of administration, the combination of drugs, the involvement of organs/systems and the main clinical symptoms of ADR. Results: Among 167 children with ADR, Doctors were the main informants(96.41%). 96 (57.48%) boys and 71 (42.52%) girls . 98 cases(58.68%) of children occurred at the age of 0~3. β-lactams and nutritional drugs ranked first and second in the top 10 drugs,respectively. Intravenous drip(47.31%) was the main route to induce ADR. 53 cases (31.74%) were caused by single drug use. There were 110 cases (65.87%) of ADR caused by combination of two drugs. ADR involved multiple organ/system damages, there were 105 cases (60.69%) of skin and appendages damage, 27 cases (15.61%) of systemic damage and 11 cases (6.36%) of digestive system damage. The main clinical symptoms were rash (49.13%), allergy (7.51%) and fever (6.94%). Conclusion: We should strengthen the monitoring of ADR in children, strengthen the supervision of intravenous administration, the combination of drugs and use of antibiotics, standardize the rational use of clinical drugs in children, reduce the occurrence of ADR and ensure the safety of drug use in children. |