| 李茜,刘英.离子色谱法分析氨基糖苷类抗菌药物的质量标准研究进展[J].中国药事,2019,33(7):819-828 |
| 离子色谱法分析氨基糖苷类抗菌药物的质量标准研究进展 |
| On the Progress in the Quality Standards of Aminoglycoside Antibiotics by Ion Chromatography |
| 投稿时间：2019-03-26 |
| DOI：10.16153/j.1002-7777.2019.07.016 |
| 中文关键词: 氨基糖苷类 抗菌药物 离子色谱 药典标准 质量控制 |
| 英文关键词: aminoglycoside antibiotics ion chromatography standards of pharmacopoeia quality control |
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| 摘要点击次数: 1459 |
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| 中文摘要: |
| 目的：综述各国药典中离子色谱法分析氨基糖苷类抗菌药物的质量标准进展情况。方法：介绍了氨基糖苷类抗菌药物的发展历程及离子色谱原理，概述了各国药典中氨基糖苷类抗菌药物的质量标准变迁，分析了各国药典离子色谱法在该类药物中的应用与质量标准沿革，并探讨了离子色谱法测定该类药物的发展趋势。结果与结论：氨基糖苷类抗菌药物的分析方法逐渐从薄层色谱法、高效液相色谱衍生化法、高效液相色谱-蒸发光散射法向离子色谱法发展，并日益成为该类抗菌药物较理想的质量控制方法，为今后氨基糖苷类抗菌药物的标准提高及质量控制提供了参考。 |
| 英文摘要: |
| Objective:To make a literature review of the research progress in the quality standards of aminoglycoside antibiotics by ion chromatography in pharmacopoeias of various countries. Methods:The development history and the principle of ion chromatography were introduced. The changes of the quality standards of aminoglycoside antibiotics in pharmacopoeias of various countries were summarized. The applications of ion chromatography in pharmacopoeias of various countries and the development of quality standards of aminoglycoside antibiotics were also analyzed. Moreover, the development trend of ion chromatography used to determine such drugs was discussed. Results and Conclusion:The analytical methods of aminoglycoside antibiotics have gradually developed from TLC, HPLC derived method and HPLC-ELSD method to ion chromatography. Ion chromatography has gradually become an ideal quality control method for aminoglycoside antibiotics, which provides references for the standard improvement and quality control of aminoglycoside antibiotics in the future. |
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