| 王珂,董培智,申国华,张禄,梁卜文,郭景文.保健食品中非法添加西地那非衍生物的确证[J].中国药事,2019,33(4):429-434 |
| 保健食品中非法添加西地那非衍生物的确证 |
| Confirmation of Sildenafil Derivatives Illegally Added in Health Foods |
| 投稿时间：2018-12-17 |
| DOI：10.16153/j.1002-7777.2019.04.013 |
| 中文关键词: 保健食品 非法添加 西地那非衍生物 PDE-5抑制剂 去甲基卡波地那非 液质联用 核磁共振 |
| 英文关键词: health foods illegally added sildenafil derivatives PDE-5 inhibitor Desmethyl Carbodenafil liquid chromatograph-mass spectrometer nuclear magnetic resonance |
| 基金项目: |
|
| 摘要点击次数: 2049 |
| 全文下载次数: 797 |
| 中文摘要: |
| 目的：对在保健食品中发现的一种非法添加的西地那非衍生物进行确证。方法：采用高效液相色谱-二极管阵列检测器（HPLC-DAD）技术在日常检测保健食品非法添加时发现一种新型西地那非衍生物。经制备液相法分离纯化得到该化合物，采用高效液相色谱-二级质谱联用（LC-MS/MS）技术获得该化合物准分子离子和碎片离子，并进一步通过核磁共振氢谱确认，结合文献分析，最终确证该化合物。结果：该化合物分子式C23H30N6O3，分子量438，结构为去甲基卡波地那非。结论：去甲基卡波地那非在国内未被报道，是一种新型PDE-5抑制剂。 |
| 英文摘要: |
| Objective: To confirm one kind of sildenafil derivatives illegally added in health foods. Methods: A novel sildenafil derivative was observed in a routine screening for compounds illegally added in heath foods by HPLC-DAD. The compound was purified by preparative HPLC. Its quasi-molecular ion and MS2 fragmentation spectrum were obtained by UPLC-MS/MS and was further confirmed by 1H-NMR. The structure of the compound was elucidated by analysis of these data and literature review. Results: The formula of this compound was C23H30N6O3 with molecular weight of 438, and the structure was Desmethyl Carbodenafil. Conclusion: Desmethyl Carbodenafil has not been reported in China yet and is a novel PDE-5 inhibitor. |
|
查看全文
查看/发表评论 下载PDF阅读器 |
| 关闭 |