| 甘美婵,秦秀英,阮炎鹏,甄乐锋.肌注维生素K1致湿疹型皮肤反应及文献回顾[J].中国药事,2018,32(10):1449-1452 |
| 肌注维生素K1致湿疹型皮肤反应及文献回顾 |
| Eczematous Skin Reaction Caused by Intramuscular Injection of Vitamin K1 and Literature Review |
| 投稿时间：2017-09-11 |
| DOI：10.16153/j.1002-7777.2018.10.023 |
| 中文关键词: 维生素K1 肌肉注射 过敏反应 |
| 英文关键词: vitamin K1 intramuscular injection anaphylactic reaction |
| 基金项目: |
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| 中文摘要: |
| 目的：总结维生素K1注射液肌肉注射后引起皮肤反应的临床特征及治疗方法。方法：对1例产妇肌注维生素K1致湿疹型皮肤反应进行报道，并对相关文献报道的情况进行回顾性汇总分析。结果：维生素K1注射液导致的皮肤反应为非Ig E介导的Ⅳ型过敏反应，主要由增溶剂聚山梨酯80所引起，抗过敏治疗效果不显著。结论：应严格掌握用药的适应证，加强用药监测，提高用药警惕性，保障患者用药安全。 |
| 英文摘要: |
| Objective: To summarize the clinical characteristics and the treatment of skin reaction caused by intramuscular injection of vitamin K1. Methods: A puerperal case of eczematous skin reaction caused by intramuscular injection of vitamin K1 was reported and the relevant literature was retrospectively analyzed. Results: The skin reaction caused by intramuscular injection of vitamin K1 was non-IgE-mediated type IV anaphylactic reaction, which was incurred by the solubilizer Polysorbate 80. Therefore, the effect of antianaphylactic treatment was not significant. Conclusion: The physicians should strictly control indications of the drug use, strengthen the monitoring of medication, increase the vigilance of medication and ensure patients the medication safety. |
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