| 舒阳,潘群.我院2010-2017年氨曲南使用强度与病原菌耐药率相关性分析[J].中国药事,2018,32(10):1444-1448 |
| 我院2010-2017年氨曲南使用强度与病原菌耐药率相关性分析 |
| Correlation Analysis between the Use Density of Aztreonam and the Resistance Rate of Pathogens in Our Hospital from 2010 to 2017 |
| 投稿时间：2018-05-21 |
| DOI：10.16153/j.1002-7777.2018.10.022 |
| 中文关键词: 氨曲南 细菌耐药率 相关性 使用强度 病原菌 |
| 英文关键词: aztreonam the resistance rate of bacteria correlation the use density pathogen |
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| 中文摘要: |
| 目的：研究氨曲南使用强度与医院内病原菌耐药率的相关性，为提高临床合理用药水平、控制病原菌对氨曲南耐药性的增长提供理论依据。方法：回顾性分析医院2010-2017年氨曲南的使用强度（AUD）和同期3种病原菌对氨曲南的耐药率，用SPSS软件分析两者的相关性。结果：氨曲南在2010-2012年间使用强度逐年上升，经过抗菌药物专项整治活动，2013年起呈下降趋势。2010-2017年间医院检出的主要革兰阴性病原菌为铜绿假单胞菌、肺炎克雷伯菌和大肠埃希菌。其中铜绿假单胞菌对氨曲南的耐药率与其AUD有显著相关性（r=0.924，p=0.001），大肠埃希菌对氨曲南的耐药率与其AUD亦有显著相关性（r=0.908，p=0.002），肺炎克雷伯菌对氨曲南的耐药率与其AUD无相关性（r=0.449，p=0.264）。结论：住院患者AUD下降，铜绿假单胞菌和大肠埃希菌的耐药率呈现下降趋势，提示临床应考虑抗菌药物对病原菌耐药的选择性筛选作用。 |
| 英文摘要: |
| Objective: To explore the correlation between the use density of aztreonam and the resistance rate of pathogens in our hospital and to provide a theoretical basis for improving the rational use of drugs clinically and controlling the growth of resistance to aztreonam. Methods: The antibiotics use density (AUD) of aztreonam from 2010 to 2017 in the hospital and the resistance rates of three kinds of pathogens to aztreonam in the same period were retrospectively analyzed. The correlation between the two items was analyzed by SPSS software. Results: The use density of aztreonam increased year by year from 2010 to 2012 and it has been decreasing since 2013 through the special rectification activities of antimicrobial drugs. The main gram negative pathogens detected in the hospital from 2010 to 2017 were Pseudomonas aeruginosa, Klebsiella pneumoniae and Escherichia coli. The resistance rate of Pseudomonas aeruginosas to aztreonam was significantly correlated with its AUD (r=0.924, p=0.001) and the resistance rate of Escherichia coli to aztreonam was also significantly associated with its AUD (r=0.908, p=0.002). However, the resistance rate of Klebsiella pneumoniae to aztreonam was not correlated with its AUD (r=0.449, p=0.264). Conclusion: As the AUD of the inpatients decreased, the resistance rate of Pseudomonas aeruginosa and Escherichia coli showed a downward trend, suggesting that selective screening of resistance of antibiotics to pathogens should be taken into account in clinical practice. |
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