| 张雷.红花注射液致过敏性休克危险因素的Logistic回归分析[J].中国药事,2018,32(9):1274-1278 |
| 红花注射液致过敏性休克危险因素的Logistic回归分析 |
| Logistic Regression Analysis of Risk Factors for Anaphylactic Shock Induced by Safflower Injection |
| 投稿时间：2017-10-11 |
| DOI：10.16153/j.1002-7777.2018.09.020 |
| 中文关键词: 红花注射液 过敏性休克 危险因素 Logistic回归分析 |
| 英文关键词: Safflower injection anaphylactic shock risk factors logistic regression analysis |
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| 中文摘要: |
| 目的：探讨红花注射液引起过敏性休克的危险因素，为临床安全用药提供参考。方法：通过检索文献，采用病例对照研究的方法，对红花注射液引起的过敏性休克患者和对照组共78例进行基本信息和用药情况的调查；应用Logistic回归模型进行单因素及多因素分析。结果：单因素分析具有显著意义（P< 0.05）的影响因素为年龄、联合用药、基础疾病、过敏发生时间；将其引入Logistic回归方程，经分析认为均有统计学意义（P< 0.05），其OR值分别为4.144、14.908、0.181、4.735。结论：年龄、联合用药、基础疾病、过敏发生时间为红花注射液引起过敏性休克的危险因素，临床要引起重视，减少或避免相应危害。 |
| 英文摘要: |
| Objective: To explore risk factors for anaphylactic shock induced by Safflower injection and to provide references for clinical safe drug use.Methods: Retrieval of literature was carried out and the method of case-control study was used to investigate the basic information and medication of 78 patients of anaphylactic shock group caused by Safflower injection and control group. Logistic regression model was applied to do univariate and multivariate analysis.Results: The factors having statistical significance by univariate analysis (P<0.05) were as follows:age, drug combination, basic diseases and allergic time, which were statistically significant (P<0.05) when put into the logistic regression equation. The OR values were 4.144, 14.908, 0.181 and 4.735 respectively.Conclusion: Age, drug combination, basic diseases and allergic time are the risk factors for anaphylactic shock induced by Safflower injection. Attention should be paid clinically in order to reduce or avoid the corresponding risks. |
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