| 常艳,张夏,李进,胡昌勤.经不同无害化及资源化技术处理后头孢菌素C发酵菌渣中抗菌活性物质的变化情况[J].中国药事,2018,32(8):1088-1096 |
| 经不同无害化及资源化技术处理后头孢菌素C发酵菌渣中抗菌活性物质的变化情况 |
| Changes of Antibacterial Active Substances in Cephalosporin C Fermentation Residues after Treatments with Different Harmless and Resource-based Technologies |
| 投稿时间：2018-06-05 |
| DOI：10.16153/j.1002-7777.2018.08.013 |
| 中文关键词: 头孢菌素C发酵菌渣 抗菌活性物质 结构预测 耐β-内酰胺酶 抗生素残留 |
| 英文关键词: cephalosporin C fermentation residues antibacterial active substances structure prediction β-lactamase resistant antibiotic residues |
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| 中文摘要: |
| 目的：建立有效评价抗生素发酵菌渣无害化处理效果的手段。方法：采用敏感菌株对无害化处理菌渣的抗菌活性进行筛查，利用HPLC-MS对菌渣中残留/转化组分的结构进行推断，再结合相关化合物数据库对残留组分生物学/安全性信息进行检索。结果：所研究的4种头孢菌素C菌渣中：未经处理菌渣中具有β-内酰胺类活性物质；3种经无害化处理的菌渣中仅有1种不再具有抑菌活性，其余2种与市政污泥混合进行堆肥处理的菌渣中均产生了有别于未经处理菌渣活性的非β-内酰胺类抑菌物质。结论：在对无害化处理效果进行评价时，除利用菌渣中特定的残留抗生素为评价指标外，还应考虑堆肥过程中菌渣残留成分的生物转化问题。 |
| 英文摘要: |
| Objective:To establish a method to effectively evaluate the harmless treatment effect of antibiotic fermentation residues. Methods:Sensitive strains were used to screen the antibacterial activity of harmlesstreated fermentation residues. The structures of residual or transformed components were inferred by HPLCMS. The biological and safety information of these components were retrieved in relevant compound public databases. Results:The untreated Cephalosporin C fermentation residues contained β-lactamase active substances among the 4 cephalosporin C residues that are tested. Among the three kinds of fermentation residues treated by harmless treatments, only one kind no longer had antibacterial activities, the other 2 kinds which were treated by composting together with city waste of sludge contained non β-lactamase active substances that were different from the activity of untreated residues. Conclusion:The effect of harmless treatment can be evaluated by specific residual antibiotics in the residues. Moreover, the bioconversion of residual substances in the composting process should also be considered. |
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