| 周宇,傅启伟,黄牡婵.棕榈酸帕利哌酮长效针剂治疗精神疾病双相障碍近远期效果分析[J].中国药事,2018,32(6):799-803 |
| 棕榈酸帕利哌酮长效针剂治疗精神疾病双相障碍近远期效果分析 |
| Short-term and Long-term Effects of Paliperidone Palmitate Long-acting Injection in Treating Mental Illness in Bipolar Disorder |
| 投稿时间：2017-06-17 |
| DOI：10.16153/j.1002-7777.2018.06.017 |
| 中文关键词: 棕榈酸帕利哌酮 长效针剂 精神疾病 双相障碍 个人和社会功能 |
| 英文关键词: paliperidone palmitate long-acting injection mental illness bipolar disorder personal and social functions |
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| 中文摘要: |
| 目的：探讨棕榈酸帕利哌酮长效针剂治疗精神疾病双相障碍的近远期效果。方法：选择2012年9月到2016年6月海南省安宁医院精神科收治的精神疾病双相障碍130例作为研究对象，根据随机信封抽签原则分为观察组与对照组各65例，对照组给予口服阿立哌唑治疗，观察组给予棕榈酸帕利哌酮长效针剂治疗，治疗观察时间为2个月。结果：治疗后的对照组和观察组总有效率分别是90.8%和98.5%，观察组显著高于对照组（P<0.05）。治疗后观察组和对照组的PSP评分分别是（75.33±14.29）分和（62.87±16.02）分，都明显高于治疗前的（48.24±15.02）分和（47.11±12.85分）（P<0.05），且治疗后观察组的PSP评分也明显高于对照组（P<0.05）。观察组的不良反应发生率为40.0%，对照组为36.9%，两组不良反应发生情况对比无明显差异（P>0.05），且不良反应程度均较轻微。结论：棕榈酸帕利哌酮长效针剂治疗精神疾病双相障碍能提高治疗效果，且应用安全性比较好，有利于改善患者的个人和社会功能，有很好的临床应用价值。 |
| 英文摘要: |
| Objective:To investigate the short-trem and long-term effects of paliperidone palmitate long-acting injection in Treating mental illness in bipolar disorder. Methods:130 patients with mental illness in bipolar disorder treated in the Department of Psychiatry of our hospital from September 2012 to June 2016 were selected as the research objects and were equally divided into the observation group and the control group with 65 patients each according to the principle of random envelope draw. The control group was orally given aripiprazole and the observation group was given paliperidone palmitate long-acting injection. The therapeutic observation time was 2 months. Results:After treatment, the total effective rates of the observation group and the control group were 98.5% and 90.8% respectively, so the total effective rate of the observation group was significantly higher than that of the control group (P<0.05). The PSP scores after treatment in the observation group and the control group were 75.33±14.29 points and 62.87±16.02 points respectively, which were significantly higher than those before treatment with 48.24±15.02 points and 47.11±12.85 points respectively (P<0.05), and the PSP score in the observation group was significantly higher than that in control group (P<0.05). The adverse reaction rate of the observation group during treatment was 40.0% and the control group's was 36.9%. There was no significant difference in the adverse reaction rate between the two groups (P>0.05), and the severity of adverse reactions was mild. Conclusion:Paliperidone palmitate long-acting injection in treatment of mental illness in bipolar disorder could improve the therapeutic effect, and its safety of application was better, which was beneficial to the improvement of the personal and social functions of the patients and had good clinical application values. |
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