| 牛素梅,张驰,钱智磊.复方甘草酸苷治疗利福平所致药物性肝损伤的药学监测与临床评价[J].中国药事,2018,32(5):647-650 |
| 复方甘草酸苷治疗利福平所致药物性肝损伤的药学监测与临床评价 |
| Pharmaceutical Monitoring and Clinical Evaluation of Compound Glycyrrhizin in the Treatment of Drug-induced Liver Injury by Rifampicin |
| 投稿时间：2017-11-15 |
| DOI：10.16153/j.1002-7777.2018.05.013 |
| 中文关键词: 复方甘草酸苷注射液 药物性肝损伤 临床评价 利福平 |
| 英文关键词: compound glycyrrhizin injection drug-induced liver injury clinical evaluation Rifampicin |
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| 中文摘要: |
| 目的：探讨采用复方甘草酸苷治疗由利福平引发的药物性肝损伤的临床效果与作用机制。方法：对南京市胸科医院急诊内科于2017年1月-2017年6月收治的60例由利福平引起的药物性肝损伤患者，采用复方甘草酸苷注射液治疗，在患者用药前和用药1天后对外周血中谷丙转氨酶、谷草转氨酶、总胆红素、碱性磷酸酶、γ-谷氨酰转移酶的含量进行检测，同时对患者的治疗周期和治疗效果进行评估。数据以SPSS 20.0软件进行统计学分析，当P<0.05时，则认为数据间的差异具有统计学意义。结果：经过治疗后，患者外周血谷丙转氨酶、谷草转氨酶、总胆红素、碱性磷酸酶、γ-谷氨酰转移酶的水平明显低于治疗前，且数据间差异具有统计学意义。结论：复方甘草酸苷注射液能够有效改善由利福平引发的药物性肝损伤患者的临床指标并加快患者康复。 |
| 英文摘要: |
| Objective:To explore the clinical effects and mechanisms of compound glycyrrhizin in the treatment of drug-induced liver injury by Rifampicin. Methods:Sixty patients with drug-induced liver injury by Rifampicin from the department of emergency of Nanjing thoracic hospital from January 2017 to June 2017 were treated with compound glycyrrhizin injection. The levels of ALT, AST, Bilirubin, ALP, and γ-GT in peripheral blood were measured before treatment and one day after treatment. Moreover, the treatment cycle and treatment effects were evaluated. The data were statistically analyzed by SPSS 20.0 software and the differences were considered statistically signifcant when P<0.05. Results:The levels of ALT, AST, Bilirubin, ALP, and γ-GT in peripheral blood after treatment were signifcantly lower than those before treatment, and the differences between the data were statistically signifcant. Conclusion:Compound glycyrrhizin injection can effectively improve the clinical indexes of patients with drug-induced liver injury by Rifampicin and accelerate the rehabilitation. |
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