| 王伟,祁永飞,包晗,邱鹏程,张鑫磊,王玉琨.基于医药大数据建立精准药学临床评估体系的思考[J].中国药事,2017,(12):1478-1482 |
| 基于医药大数据建立精准药学临床评估体系的思考 |
| Establishment of the Clinical Evaluation System of Precision Pharmacy Based on Medical Big Data |
| 投稿时间：2017-06-15 |
| DOI：10.16153/j.1002-7777.2017.12.018 |
| 中文关键词: 精准药学 大数据 个体化用药 药物基因组 临床评估 |
| 英文关键词: precision pharmacy big data personalized medicine pharmacogenomics clinical evaluation |
| 基金项目:国家自然科学基金项目（编号81702733）；肿瘤生物学国家重点实验室项目（编号CBSKI2015Z14，CBSKI201713）；陕西省科技统筹创新工程（2016KTCL03-09） |
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| 中文摘要: |
| 目的：探讨医药大数据服务于精准药学的现有问题和对策。方法：通过文献资料，分析精准药学临床应用所需的大数据及其发展现状，从药物基因组学研究和个体基因组学研究的角度，探讨目前个体化用药研究的局限性。结果与结论：现有的药物基因组学研究成果远远不能满足临床需求，而基因组学研究成果过于碎片化，难以应用于临床。整合临床电子健康记录（EHR）的基因组研究，能反映药物研发和应用的实效；建立依据EHR和组学数据的精准药学临床评估体系，将大大提高精准药物研发和个体化用药的循证性和准确性。 |
| 英文摘要: |
| Objective: To explore the existing problems and countermeasures of medical large data service in precision pharmacy. Methods: Big data required in clinical application of precision pharmacy and development status at present were analyzed based on literature review and logical analysis. The limitations of current personalized medicine researches were explored from the perspectives of pharmacogenomics and individual genomics studies. Resuults and Conclusion: Current achievements of pharmacogenomics studies couldn't meet clinical requirement. The achievements of individual genomics studies were too fragmented to be used in clinic. The genomic studies combined with electron health records (EHR) could reflect the research and development of drugs and the effectiveness of medication to some extent. The establishment of the clinical evaluation system of precision pharmacy based on EHR and omics data would greatly promote the research and development of precision drug and the evidence-based accuracy of personalized medicine. |
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