文章摘要
闵春艳,游本刚,吴杨,郭青,狄恒建,顾炳仁.UPLC法评价硫磺熏蒸对西洋参皂苷类成分的影响[J].中国药事,2017,(11):1297-1303
UPLC法评价硫磺熏蒸对西洋参皂苷类成分的影响
Evaluation of the Effect of Sulfur Fumigation on Ginsenosides in Panax Quinquefolium by UPLC
投稿时间：2017-01-22  
DOI：10.16153/j.1002-7777.2017.11.014
中文关键词: 硫磺熏蒸  西洋参  人参皂苷Rg1,Re,Rb1  UPLC
英文关键词: sulfur fumigation  panax quinquefolium  ginsenoside Rg1,Re,Rb1  UPLC
基金项目:中国药典2015版一部科研项目-未经硫磺熏蒸中药材中药饮片性状修订研究；苏州市社会发展项目-中药材生产加工过程中质量检测和控制关键技术研究（编号SS201330）
作者单位E-mail
闵春艳 苏州市药品检验检测研究中心, 苏州 215104
苏州大学, 苏州 215123 		 
游本刚 苏州大学, 苏州 215123  
吴杨 苏州市药品检验检测研究中心, 苏州 215104  
郭青 江苏省食品药品监督检验研究院, 南京 210008 494615112@qq.com 
狄恒建 江苏省食品药品监督检验研究院, 南京 210008  
顾炳仁 苏州市药品检验检测研究中心, 苏州 215104  
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中文摘要:
      目的：评价硫磺熏蒸对西洋参皂苷类成分的影响。方法：建立超高效液相色谱法，测定并比较分析硫磺熏蒸前后西洋参中人参皂苷Rg1、Re和Rb1的含量。结果：硫磺熏蒸后西洋参中人参皂苷Rg1、Re和Rb1总量仍符合《中国药典》规定；但当硫磺熏蒸致二氧化硫残留量大于400 mg·kg-1时，人参皂苷Re、Rb1的含量及人参皂苷Rg1、Re和Rb1三者的总量显著降低。当二氧化硫残留量不大于150 mg·kg-1时，人参皂苷Rg1、Re和Rb1的含量及其总量基本不受影响。结论：《中国药典》规定的西洋参二氧化硫残留量不得大于150 mg·kg-1有其科学合理性，硫磺过度熏蒸西洋参（二氧化硫残留量大于400mg·kg-1）对西洋参中皂苷类成分的含量有显著影响。
英文摘要:
      Objective: To evaluate the effect of sulfur fumigation on ginsenosides in panax quinquefolium. Methods: A UPLC method was established to measure the contents of ginsenoside Rg1, Re and Rb1 in panax quinquefolium before and after sulfur fumigation. The results were compared using variance analysis method. Results: The total contents of ginsenoside Rg1, Re and Rb1 in sulfur-fumigated panax quinquefolium met the criterion of Chinese Pharmacopeia. However, the contents of ginsenoside Re and Rb1 as well as the total contents of ginsenoside Rg1, Re and Rb1 signifcantly decreased compared with the non-fumigated panax quinquefolium when the sulfur dioxide residue in panax quinquefolium was more than 400 mg·kg-1. The contents of ginsenoside Rg1, Re, Rb1 and the contents of ginsenoside Rg1, Re and Rb1 in panax quinquefolium were not affected by sulfur fumigation when the sulfur dioxide residue of panax quinquefolium was not more than 150 mg·kg-1. Conclusion: That the sulfur dioxide residue of panax quinquefolium should not be more than 150 mg·kg-1 provided by Chinese Pharmacopeia was reasonable. Over sulfur fumigation on panax quinquefolium would signifcantly affect the contents of ginsenosides in panax quinquefolium.
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