| 李佳,林炽雄,范玉华,何秋毅,闫佳佳,陈杰,陈孝.非ICU住院患者利奈唑胺的临床用药合理性调查[J].中国药事,2017,(3):328-336 |
| 非ICU住院患者利奈唑胺的临床用药合理性调查 |
| Rationality Investigation of Linezolid in Clinical Application for Non-ICU Inpatients |
| 投稿时间：2016-09-28 |
| DOI：10.16153/j.1002-7777.2017.03.016 |
| 中文关键词: 恶唑烷酮类抗菌药物 利奈唑胺 非危重症 合理用药 疗效调查 不良反应 非ICU 病例分析 |
| 英文关键词: oxazolidinone antibacterial Linezolid non-intensive critical care unitillness rational drug use efficacy survey ADR non-ICU case analysis |
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| 中文摘要: |
| 目的： 评价中山大学附属第一医院非ICU住院患者使用利奈唑胺的临床合理性及其疗效和安全性,为非ICU科室的临床合理用药提供参考。方法：采用回顾性研究方法，选取我院非ICU科室2015年1月-2015年12月使用利奈唑胺注射剂或片剂的患者病例，根据药品说明书和相关指南，分析利奈唑胺的临床应用合理性，并统计有效率及不良反应发生率。结果：调查共纳入有效病例112例，其中用药合理为77例（68.75%），用药不合理35例（31.25%）：用药无指征6例（5.36%），用药疗程不适宜15例（13.39%），联合用药不当11例（9.82%），8.04%的患者联用了4种以上抗菌药物。治疗结果痊愈72例，无效33例，因不良反应难以耐受停用5例，因缺药停用2例，临床治疗有效率为68.57%。用药后出现不良反应的有26例（23.21%）。结论：利奈唑胺在治疗非ICU科室患者的革兰氏阳性球菌感染时临床疗效较好，但存在不合理使用情况，使用过程中需关注其不良反应的发生。 |
| 英文摘要: |
| Objective: To appraise the rationality of clinical use of linezolid in non-ICU departments, as well as its efficacy and safety. Methods: A retrospective study was conducted in patients treated with LZD injection or tablets between January 2015 and December 2015 from the non-ICU departments of a tertiary hospital in Guangzhou. The rationality of linezolid, the effective rate and incidence of adverse reactions (ADR) were analyzed, referring to the drug instruction and relevant guidelines. Results: Among the 112 patients included, there were 77 cases for rational use (68.75%) and 35 cases unreasonable (31.25%); among irrational drug use, there were 6 cases having no clear indications (5.36%), 15 cases with too long or too short duration of treatment (13.39%), and 11 cases of improper combination with other antibiotics (9.82%), 8.04% of which were involved in combination with more than four kinds of antibiotics. 72 patients were cured, while 33 were invalid; 5 were discontinued due to difficulty into tolerating ADR and 2 stopped using because of deficiency of drug, resulting in an effective rate of 68.57%. ADRs were observed in 26 cases (23.21%) after medication. Conclusion: There were irrational phenomena in clinical use of Linezolid at non-ICU departments, although it showed a relatively better therapeutic effect on Gram-positive bacteria infections. ADRs should be monitored closely when using linezolid. |
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