| 胡佳,黄惠英.左乙拉西坦联用维生素B6对药物不良反应的影响[J].中国药事,2017,(1):112-115 |
| 左乙拉西坦联用维生素B6对药物不良反应的影响 |
| Effects of Levetiracetam Combined with Vitamin B6 on the Adverse Drug Reactions |
| 投稿时间：2016-08-02 |
| DOI：10.16153/j.1002-7777.2017.01.022 |
| 中文关键词: 抗癫痫药物 左乙拉西坦 维生素B6 联合用药 行为不良反应 病例分析 |
| 英文关键词: antiepileptic drug Levetiracetam Vitamin B6 drug combination behavioral side effects case analysis |
| 基金项目: |
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| 中文摘要: |
| 目的：观察左乙拉西坦与维生素B6联用对其药物不良反应的影响。方法：回顾性分析2010年1月-2015年6月就诊于神经内科癫痫专科并随访大于24周的患者110例。根据自愿原则将110例门诊患者随机分为研究组（左乙拉西坦+维生素B6）和对照组（单用左乙拉西坦），在治疗后的4、12、24周动态随访其疗效和不良反应。结果：治疗24周后，研究组行为的不良反应包括兴奋、攻击、烦躁、激惹等副作用的出现明显低于对照组（P<0.05）。结论：联用维生素B6对左乙拉西坦药物不良反应的影响有一定的改善。 |
| 英文摘要: |
| Objective: To observe the effects of Levetiracetam combined with Vitamin B6 on the adverse drug reactions. Methods: A total of 110 cases of patients with epilepsy who received more than 24-week from the Epilepsy clinic of the Leshan Hospital between Jan. 2010 and Jun. 2015 were retrospectively analyzed. The 110 patients were randomly divided into the study group (Levetiracetam+Vitamin B6) and the control group (Levetiracetam only) according to the voluntary principles, and dynamic follow-ups of the curative effects and adverse reactions were conducted in the 4th, 12th, and 24th week after the treatment. Results: The incidence of adverse reactions (including excitement, aggressive behavior, irritability, and other side effects) in the study group was significantly lower than that in the control group after 24-week treatment (P<0.05). Conclusion: The treatment combining with Vitamin B6 could relieve the adverse drug reactions caused by Levetiracetam to a certain degree. |
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