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| 光响应生物材料研究进展及应用 |
| Photo-Responsive Biomaterials：Development and Applications |
| 投稿时间：2019-06-21 修订日期：2019-09-23 |
| DOI： |
| 中文关键词: 刺激响应材料 光响应生物材料 光敏官能团 光化学反应机理 药物控释系统 组织工程支架 |
| 英文关键词: stimuli-responsive materials photo-responsive biomaterials photo sensitive functional moieties photochemical reaction mechanisms drug controlled release tissue engineering scaffold |
| 基金项目:国家重点研发计划 (编号 2016YFC1101202) |
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| 摘要点击次数: 436 |
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| 中文摘要: |
| 目的：简述光响应生物材料的分类及光化学反应机理，对光响应生物材料在药物控制系统及组织工程支架方面的研究进展进行综述，讨论目前临床转化上存在的挑战和未来方向。方法：利用计算机检索万方、CNKI、PubMed及Web of science数据库，以中英文关键词“刺激响应材料；光响应生物材料；光敏官能团；光化学反应机理；药物控释系统；组织工程支架；stimuli-responsive materials；photo-responsive biomaterials；photo sensitive functional moieties；photochemical reaction mechanisms；drug controlled release；tissue engineering scaffold”进行检索，最终共纳入56篇文献进行综述。
结果：由于光源具有很多优点，例如在时间和空间上精确可控、容易操作等,使得光响应生物材料在生物医药领域得到广泛的关注。尽管近年来光响应生物材料基础理论研究已经取得巨大进展，但是在临床转化中仍存在很大的问题和挑战，例如光化学反应以紫外光作为激发光源，光响应生物材料生物相容性的问题等。
结论：新材料研发上的创新，例如制备出对近红外光响应的生物材料或者兼具对多种刺激如光、pH、酶等有响应的生物材料，将会给光响应生物材料在医疗领域应用带来更大希望。 |
| 英文摘要: |
| OBJECTIVE: To systemically introduce classifications and photochemical reaction mechanisms of photo-responsive materials, to discuss the applications of photo-responsive materials in the biomedical fields such as drug controlled release and tissue engineering scaffold, and to briefly describe the challenges in clinical translation and potential future directions for photo-responsive biomaterials.
METHODS: We searched WanFang, CNKI, PubMed and web of science databases for relevant articles. The keywords were “stimuli-responsive materials；photo-responsive biomaterials； photo sensitive functional moieties；photochemical reaction mechanisms；drug controlled release；tissue engineering scaffold” in Chinese and English, respectively. Fifty-six publications were in included in the final analysis.
RESULTS: As light can be controlled spatially and temporally with great easy and convenience, photo-responsive materials have attracted significant attentions in biomedical fields during the past decades. Although much effort has been devoted to investigating well-known photo sensitive functional moieties to meet the demands for different biomedical fields, most of the present research is still restricted at the experimental level. There are several key challenges that need to be resolved, such as materials excitation with UV light and biocompatibility of photo-responsive materials.
CONCLUSION：With the innovations of new materials which can be excitated with near-infrared(NIR) light or controlled by much stimulus such as light、 pH and enzymes, it will bring more opportunities to fulfill the demands in biomedical fields. |
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