| 曹辉,殷萍萍,沈洁.我院人用狂犬病疫苗及狂犬病人免疫球蛋白使用情况分析[J].中国药事,2019,33(2):229-234 |
| 我院人用狂犬病疫苗及狂犬病人免疫球蛋白使用情况分析 |
| Analysis of the Use of Human Rabies Vaccine and Human Rabies Immunoglobulin in Our Hospital |
| 投稿时间：2018-07-10 |
| DOI：10.16153/j.1002-7777.2019.02.019 |
| 中文关键词: 人用狂犬病疫苗 狂犬病人免疫球蛋白 季节指数 不良反应 |
| 英文关键词: human rabies vaccine human rabies immunoglobulin seasonal index adverse reaction |
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| 中文摘要: |
| 目的：总结分析2015-2017年我院人用狂犬病疫苗及狂犬病人免疫球蛋白（HRIG）的使用情况，为科学、合理地制定采购计划及储备管理提供依据。方法：通过医院信息管理系统调取2015-2017年我院人用狂犬病疫苗及HRIG的相关使用数据，计算其月占比、季节指数等数据，对我院2015-2017年人用狂犬病疫苗及HRIG的使用情况进行分析。结果：2015-2017年我院人用狂犬病疫苗共使用484166支，分别为145140支、154818支、184208支，使用总量逐年增加。其中5-10月使用量最大，季节指数均超过100%；12月至来年3月接种量使用量相对较小，季节指数均不超过80%。3年间HRIG的使用总量也逐年明显增加，季节指数的变化与人用狂犬病疫苗相似。结论：2015-2017年我院人用狂犬病疫苗及HRIG的使用量基本呈现夏秋季多、冬春季少的规律，具有典型的季节性。根据时间序列方程式计算得到的2018年人用狂犬病疫苗预测使用数量与实际使用数量并不相符，误差率较大，易受外界因素影响。因此，还是要根据季节及实际使用情况的变化，动态地进行人用狂犬病疫苗及HRIG的库存管理。人用狂犬病疫苗在使用中发现的不良反应多为局部反应，但我院近年来也偶发非常严重的不良反应，因此要加强观察，提高重视。 |
| 英文摘要: |
| Objective: To summarize and analyze the use of human rabies vaccine and human rabies immunoglobulin (HRIG) in our hospital from 2015 to 2017, and to provide a basis for scientific and rational development of procurement planning and reserve management. Methods: Data of the use of human rabies vaccine and HRIG in our hospital from 2015 to 2017 were collected through the hospital information management system. The monthly ratio and seasonal index and so on were calculated to analyze the use of human rabies vaccine and HRIG in our hospital from 2015 to 2017. Results: A total of 484166 rabies vaccines were used in our hospital from 2015 to 2017, 145140, 154818 and 184208, respectively. The total number increased year by year. The inoculation number was the largest from May to October and the seasonal index was more than 100%. The inoculation number was relatively small from December to next March and the seasonal index was not more than 80%. The total number of HRIG had also increased significantly over the past three years and the change of the seasonal index was similar to that of the human rabies vaccine. Conclusion: The use of human rabies vaccine and HRIG in our hospital basically showed the pattern that there were more cases in summer and autumn, less in winter and spring, with typical seasonality from 2015 to 2017. According to the time series equation, the predicted number of human rabies vaccine used in 2018 was not consistent with the actual number used so far, and the error rate was high, which wass susceptible to external factors. Therefore, it is necessary to dynamically carry out inventory management of human rabies vaccine and HRIG according to the changes of seasons and actual use. The adverse reactions found in the use of human rabies vaccine are mostly local reactions. However, very serious adverse reactions have occasionally occurred in our hospital in recent years. Therefore, it is necessary to strengthen observation and pay more attention to it. |
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